Rock2 stabilizes β-catenin to promote tumor invasion and metastasis in colorectal cancer
Rock2 stabilizes β-catenin to promote tumor invasion and metastasis in colorectal cancer
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Rock2稳定β-连环蛋白促进结直肠癌的肿瘤侵袭和转移
DOI：
10.1016/j.bbrc.2015.10.103
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发表时间：
2015-11-27
影响因子：
3.1
通讯作者：
Shao, Jianghua
中科院分区：
文献类型：
--
作者：
Qiu, Yumin;Yuan, Rongfa;Shao, Jianghua
Rho-associated coil- coil-containing protein kinase 2 （Rock2）是Rho小GTPase的效应器，在肿瘤的进展和转移中起重要作用。然而，Rock2在结直肠癌（CRC）中的作用尚不清楚。在本研究中，我们发现Rock2在临床结直肠癌组织中的表达与邻近非癌组织相比明显升高。Rock2在结直肠癌中高表达与肿瘤转移及预后不良相关。此外，在体外和体内，Rock2的敲低抑制了CRC细胞的侵袭和转移。此外，我们发现β -catenin/TCF4通路参与了Rock2在CRC细胞中的作用，Rock2通过阻止β -catenin的泛素化和降解来稳定β -catenin。综上所述，这种β -连环蛋白控制的新途径在结直肠癌转移中起着生物学相关的作用。(C) 2015爱思唯尔公司版权所有。
Rho-associated coiled-coil-containing protein kinase 2 (Rock2) is an effector for the small GTPase Rho and plays an important role in tumor progression and metastasis. However, the effect of Rock2 in colorectal cancer (CRC) still remains unclear. In this study, we found that Rock2 expression was markedly increased in clinical CRC tissues compared with adjacent non-cancerous tissues. High expression of Rock2 was correlated with tumor metastasis and poor prognosis in CRC. In addition, the knockdown of Rock2 suppressed the invasion and metastasis of CRC cells both in vitro and in vivo. Furthermore, we found that the beta-catenin/TCF4 pathway contributed to the effects of Rock2 in CRC cells, and Rock2 stabilized beta-catenin by preventing its ubiquitination and degradation. Taken together, this novel pathway for beta-catenin control plays a biologically relevant role in CRC metastasis. (C) 2015 Elsevier Inc. All rights reserved.