Cell Biology: Regulating G Protein Signaling
Cell Biology: Regulating G Protein Signaling
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细胞生物学：调节 G 蛋白信号传导
DOI：
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发表时间：
1996
期刊：
影响因子：
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通讯作者：
W. Roush
中科院分区：
文献类型：
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作者：
W. Roush
细胞生物学家早就知道，细胞可以抑制它们对激素、神经递质和其他调节剂的反应，但这种“脱敏”到底是如何发生的还不清楚。现在，几个实验室的一系列工作正在揭示一组主要的细胞内通讯线路--那些使用G蛋白向细胞内部传输信号的线路--是如何实现音量控制的。研究人员已经确定了一种新的蛋白质家族，称为RGS蛋白质(调节G蛋白信号)，通过这些途径减弱信号，显然是通过与组成完整G蛋白的三个蛋白质亚基之一结合来实现的。这些新的发现可能会让人们更好地理解G蛋白信号通路是如何工作的--这些信息可能具有实际意义，因为多达60%的药物通过这些途径发挥作用。
Cell biologists have long known that cells can damp down their responses to hormones, neurotransmitters, and other regulators, but exactly how this “desensitization” occurs has been unclear. Now a flurry of work from several labs is revealing how one major group of intracellular communication lines—those using G proteins to transmit signals to the cell interior—achieves this volume control. Researchers have identified a new family of proteins, known as the RGS proteins (for regulators of G protein signaling), that attenuate signaling through those pathways, apparently by binding to one of the three protein subunits that make up a complete G protein. The new findings could lead to a much better understanding of how G protein-signal pathways work—information that could have practical implications as up to 60% of all drugs exert their effects through these pathways.