Association between serum leptin and bone metabolic markers, and the development of heterotopic ossification of the spinal ligament in female patients with ossification of the posterior longitudinal ligament
Association between serum leptin and bone metabolic markers, and the development of heterotopic ossification of the spinal ligament in female patients with ossification of the posterior longitudinal ligament
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DOI：
10.1007/s00586-011-1688-7
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发表时间：
2011-09-01
影响因子：
2.8
通讯作者：
Yamazaki, Masashi
中科院分区：
文献类型：
--
作者：
Ikeda, Yoshikazu;Nakajima, Arata;Yamazaki, Masashi
肥胖是脊柱后纵韧带骨化（OPLL）的危险因素，其特征在于脊柱后纵韧带中的异位骨形成。高瘦素血症是肥胖人群的常见特征，瘦素被认为是OPLL发病的重要因素。然而，瘦素与骨代谢和OPLL的发展之间的关系尚未完全了解。本研究的目的是确定OPLL患者血清瘦素浓度和骨代谢标志物与脊柱韧带异位骨化程度之间的关系。对125例（男68例，女57例）OPLL患者的血清瘦素、胰岛素、果糖胺、骨特异性碱性磷酸酶和I型前胶原羧基末端前肽浓度、尿脱氧吡啶啉水平和OPLL受累椎体数量进行了测定。然后检查瘦素与这些其他因素之间的相关性。血清瘦素和胰岛素浓度增加显着OPLL女性相比，非OPLL女性控制。在女性OPLL患者中，经体重指数校正的血清瘦素浓度与OPLL累及的椎骨数量呈正相关。在女性中，OPLL扩展到胸椎和/或腰椎的患者血清瘦素水平显著高于OPLL仅限于颈椎的患者。我们的研究结果表明，高瘦素血症，结合高胰岛素血症，可能有助于发展的异位骨化的脊柱韧带的女性患者OPLL。
Obesity is a risk factor for ossification of the posterior longitudinal ligament (OPLL) of the spine, which is characterized by heterotopic bone formation in the posterior longitudinal spinal ligament. Hyperleptinemia is a common feature of obese people and leptin is believed to be an important factor in the pathogenesis of OPLL. However, the association between leptin and bone metabolism and the development of OPLL is not understood fully. The objective of the present study was to determine the association between serum leptin concentration and bone metabolic markers and the extent of heterotopic ossification of the spinal ligament in patients with OPLL. The serum concentrations of leptin, insulin, fructosamine, bone-specific alkaline phosphatase, and carboxyterminal propeptide of type I procollagen, urine deoxypyridinoline levels, and the number of vertebrae with OPLL involvement were measured in 125 (68 males and 57 females) patients with OPLL. The correlation between leptin and these other factors was then examined. Serum leptin and insulin concentrations were increased significantly in OPLL females compared to non-OPLL female controls. In the females with OPLL, serum leptin concentrations corrected for body mass index correlated positively with the number of vertebrae with OPLL involvement. In females, serum leptin levels were significantly higher in patients in whom OPLL extended to the thoracic and/or lumbar spine than in patients in whom OPLL was limited to the cervical spine. Our results suggest that hyperleptinemia, in combination with hyperinsulinemia, may contribute to the development of heterotopic ossification of the spinal ligament in female patients with OPLL.