Etiology of sarcoidosis
Etiology of sarcoidosis
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DOI：
10.1016/j.ccm.2008.03.011
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发表时间：
2008-09-01
影响因子：
5.7
通讯作者：
Moller, David R.
中科院分区：
文献类型：
--
作者：
Chen, Edward S.;Moller, David R.
过去十年的研究提高了我们对结节病发病机制的认识；并为这种疾病的潜在病因提供了新的见解。重要的是要记住，结节病的任何病因都必须能够引起系统性非干酪化肉芽肿的病理标志和结节病的异质性临床特征。此外，致病因子必须与免疫特征兼容，包括极化T辅助I细胞因子谱和寡克隆T细胞扩增与抗原驱动过程一致。然而，即使对这种疾病进行了研究，对结节病的病因仍缺乏共识。这一挑战可能只有通过进一步的研究来克服，这些研究包括临床、遗传、免疫、环境和微生物学在患者群体中的概况，并辅以实验模型中候选病原体的测试，这些模型概括了这种疾病的关键特征。
Research over the past decade has advanced our understanding of the pathogenesis of sarcoidosis; and provided new insights into potential causes of this disease. It is important to remember that any etiologic agent of sarcoidosis must be capable of causing the pathologic hallmark of systemic noncaseating granulomas and the heterogeneous clinical features of sarcoidosis. In addition, etiologic agents must be compatible with immunologic features, including polarized T-helper I cytokine profiles and oligoclonal T cell expansions consistent with antigen driven processes. Yet, even with studies conducted in this disease, there remains a lack of consensus on the etiology of sarcoidosis. This challenge is likely to be overcome only with additional research that incorporates clinical, genetic, immunologic, environmental, and microbiologic profiles in groups of patients, supplemented with testing of candidate pathogenic agents in experimental models that recapitulate critical features of this disease.