Term and preterm labor: decreased suppressive activity and changes in composition of the regulatory T-cell pool
Term and preterm labor: decreased suppressive activity and changes in composition of the regulatory T-cell pool
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DOI：
10.1038/icb.2012.33
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发表时间：
2012-11-01
影响因子：
4
通讯作者：
Steinborn, Andrea
中科院分区：
文献类型：
--
作者：
Schober, Linda;Radnai, Diana;Steinborn, Andrea
调节性T细胞（TCRs）在半同种异体胎儿耐受诱导中发挥关键作用。目前，免疫排斥过程是否参与正常足月或不可抗拒性早产的诱导尚不清楚。在这项研究中，我们检查了早产和足月分娩妇女的总CD 4（+）CD 127（低+/-）CD 25（+）FoxP（3+）-Treg细胞库的百分比，其抑制活性及其与不同Treg亚群（HLA-DR低+-，HLA-DR高+-，HLA-DR--和初始CD 45 RA（+）-Treg）的组成是否存在差异。我们发现，无论是在足月分娩还是早产分娩的妇女中，其百分比都没有下降。它的抑制活性在早产妇女中强烈减弱，在自发足月分娩妇女中减弱程度较小。在正常妊娠过程中，其组成发生变化，初始CD 45 RA（+）-T细胞百分比增加，而高度抑制性HLA-DR low（+）-和HLA-DR high +-T细胞百分比显著下降，直至足月。随着自然足月分娩的发生，这种现象被逆转，并在产后达到显着的值。此外，我们证实了总Treg细胞库中HLA-DR+-Tlg百分比的降低及其HLA-DR表达水平的降低（取决于HLA-DR低+-和HLA-DR高+-Tlg百分比）对早产妇女中总Treg细胞库的抑制活性具有降低作用。然而，自然足月分娩与该Treg亚群的HLA-DR+-T细胞百分比增加和HLA-DR表达增加相关。因此，很明显，诱导足月或早产的机制可能完全不同。Immunology and Cell Biology（2012）90，935-944; doi：10.1038/icb.2012.33; 2012年7月3日在线发表
Regulatory T cells (Tregs) exert a key role in tolerance induction to the semi-allogeneic fetus. Currently, it is not known whether immunological rejection processes are involved in the induction of normal term or irresistible preterm labor. In this study, we examined whether there were differences in the percentage of the total CD4(+)CD127(low+/-)CD25(+)FoxP(3+)-Treg-cell pool, its suppressive activity and its composition with distinct Treg subsets (HLA-DRlow+-, HLA-DRhigh+-, HLA-DR-- and naive CD45RA(+)-Tregs) between preterm and term laboring women. We found that its percentage was decreased neither in term nor in preterm laboring women. Its suppressive activity was strongly diminished in preterm laboring women and to a lesser extent in spontaneously term laboring women. During the normal course of pregnancy, its composition changed in such a way that the percentage of naive CD45RA(+)-Tregs increased while the percentage of the highly suppressive HLA-DRlow(+)- and HLA-DRhigh+-Tregs decreased significantly until term. With the onset of spontaneous term labor this phenomenon was reversed and reached significant values postpartum. In addition, we confirmed that both the decreased percentage of HLA-DR+-Tregs within the total Treg-cell pool and their decreased level of HLA-DR expression (depending on the percentage of HLA-DRlow+- and HLA-DRhigh+-Tregs) had a reducing effect on the suppressive activity of the total Treg cell pool in preterm laboring women. However, spontaneous term delivery was associated with increasing percentages of HLA-DR+-Tregs and increasing HLA-DR expression of this Treg subset. Therefore, it becomes apparent that the mechanisms inducing term or preterm labor may be completely different. Immunology and Cell Biology (2012) 90, 935-944; doi: 10.1038/icb.2012.33; published online 3 July 2012