Epidemiology of Inflammatory Bowel Disease in Quebec: Recent Trends
Epidemiology of Inflammatory Bowel Disease in Quebec: Recent Trends
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DOI：
10.1097/mib.0000000000000162
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发表时间：
2014-10-01
影响因子：
4.9
通讯作者：
Brassard, Paul
中科院分区：
文献类型：
--
作者：
Bitton, Alain;Vutcovici, Maria;Brassard, Paul
背景资料：根据十多年前收集的数据，在加拿大的10个省中，魁北克的克罗恩病（CD）发病率第二高。到目前为止，魁北克尚无溃疡性结肠炎（UC）发生率的报告，也无CD发生率的更新。我们试图描述魁北克2001 - 2008年炎症性肠病的年发病率和患病率的趋势。方法：采用魁北克行政卫生数据库进行一项基于人群的回顾性队列研究。IBD病例使用经验证的病例定义确定，2年内至少需要1次住院或4次医生索赔。事件病例被定义为在病例定义的2年时间跨度之前至少2年没有炎症性肠病的个体。结果：我们确定了24，377例CD和15，346例UC病例。CD和UC的平均诊断年龄分别为39岁和46岁。从2001年到2008年，CD（P < 0.003）和UC（P < 0.001）的年发病率均显著下降。在儿科病例中未发现随时间的显著变化。2008年的点患病率为每100，000人277例CD和164例UC病例。平均发病率为17.4例CD病例/100，000人-年和10.1例UC病例/100，000人-年。CD或UC.Conclusions：在2001年至2008年期间，CD和UC的年发病率在魁北克均呈下降趋势。儿童病例的发生率随时间无显著变化。
Background: Among 10 provinces in Canada, Quebec has the second highest incidence of Crohn's disease (CD), based on data collected more than a decade ago. To date, there are no reports on the occurrence of ulcerative colitis (UC) and no updates on the occurrence of CD in Quebec. We sought to describe trends in the annual incidence and prevalence of inflammatory bowel disease in Quebec during 2001 to 2008.Methods: A population-based retrospective cohort study was conducted using the administrative health databases of Quebec. IBD cases were identified using a validated case definition requiring at least 1 hospitalization or 4 physician claims within a 2-year period. Incident cases were defined as individuals who had been free of inflammatory bowel disease for at least 2 years before the 2-year time span of the case definition.Results: We identified 24,377 CD and 15,346 UC cases. The mean age at diagnosis was 39 and 46 years for CD and UC, respectively. There was a significant decline in the annual incidence from 2001 to 2008 for both CD (P < 0.003) and UC (P < 0.001). No significant change with time was found in pediatric cases. The point prevalence in 2008 was 277 CD and 164 UC cases per 100,000 population. The average incidence was 17.4 CD cases per 100,000 person-years and 10.1 UC cases per 100,000 person-years. There was no predominance of urban or rural cases for either CD or UC.Conclusions: During 2001 to 2008, annual incidence for both CD and UC declined in Quebec. There was no significant change with time in incidence for pediatric cases.