A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
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DOI：
10.1016/j.psyneuen.2014.07.014
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发表时间：
2014-11-01
影响因子：
3.7
通讯作者：
Ellenbogen, Mark A.
中科院分区：
文献类型：
--
作者：
Cardoso, Christopher;Kingdon, Danielle;Ellenbogen, Mark A.
背景：大量研究考察了鼻腔注射催产素对社会认知和压力调节的急性影响。虽然在了解催产素对临床人群(如自闭症、精神分裂症)社会认知的影响方面取得了进展，但关于其对精神障碍患者下丘脑-垂体-肾上腺(HPA)轴功能的影响知之甚少。方法：我们对鼻腔给药对皮质醇对实验室任务反应的急性影响进行了荟萃分析。这项搜索产生了18项采用随机、安慰剂对照设计的研究(k=18，N=675)。随机效应模型和调节分析使用统计程序R的Metafor软件包进行。结果：总体效应大小估计是适度的，没有统计学意义(HedgesG=-0.151，p=0.11)，在研究中这种效应具有中等的异质性(I-2=31%)。控制了基线皮质醇浓度的差异，缓和分析显示，这种影响在对HPA轴产生强烈刺激的挑战性实验室任务的反应中更大(Hedge g=-0.433，95%CI[-0.841，-0.025])，并且在临床人群中相对于健康对照组(Hedge g=-0.742，95%CI[-1.405，-0.078])。结论：总体而言，给予催产素的实验室任务对强烈激活HPA轴的皮质醇反应的减弱程度高于没有强烈激活HPA轴的实验室任务。在临床人群中，这一效果更加明显，这表明在那些有临床诊断并伴随着社交困难的人中，可能对催产素的敏感性增加。这些数据支持这样的观点，即催产素可能在与精神病理学相关的HPA功能障碍中发挥重要作用。(C)2014爱思唯尔有限公司。保留所有权利。
Background: A large body of research has examined the acute effects of intranasal oxytocin administration on social cognition and stress-regulation. While progress has been made with respect to understanding the effect of oxytocin administration on social cognition in clinical populations (e.g. autism, schizophrenia), less is known about its impact on the functioning of the hypothalamic-pituitary-adrenal (HPA) axis among individuals with a mental disorder.Method: We conducted a meta-analysis on the acute effect of intranasal oxytocin administration on the cortisol response to laboratory tasks. The search yielded eighteen studies employing a randomized, placebo-controlled design (k = 18, N = 675). Random-effects models and moderator analyses were performed using the metafor package for the statistical program R.Results: The overall effect size estimate was modest and not statistically significant (Hedges G = -0.151, p = 0.11) with moderate heterogeneity in this effect across studies (I-2 = 31%). Controlling for baseline differences in cortisol concentrations, moderation analyses revealed that this effect was larger in response to challenging laboratory tasks that produced a robust stimulation of the HPA-axis (Hedges g = -0.433, 95% CI[-0.841, -0.025]), and in clinical populations relative to healthy controls (Hedges g = -0.742, 95% CI[-1.405, -0.078]).Conclusion: Overall, oxytocin administration showed greater attenuation of the cortisol response to laboratory tasks that strongly activated the HPA-axis, relative to tasks that did not. The effect was more robust among clinical populations, suggesting possible increased sensitivity to oxytocin among those with a clinical diagnosis and concomitant social difficulties. These data support the view that oxytocin may play an important role in HPA dysfunction associated with psychopathology. (C) 2014 Elsevier Ltd. All rights reserved.