POTENTIALLY SERIOUS SIDE EFFECTS OF HIGH-DOSE TWICE-WEEKLY RIFAMPICIN
POTENTIALLY SERIOUS SIDE EFFECTS OF HIGH-DOSE TWICE-WEEKLY RIFAMPICIN
复制标题
DOI：
10.1136/bmj.3.5770.343
复制
发表时间：
1971-01-01
影响因子：
105.7
通讯作者：
WORLLEDGE, S
中科院分区：
文献类型：
--
作者：
POOLE, G;STRADLING, P;WORLLEDGE, S
49名患者每日单剂量利福平600毫克，与其他药物（通常为链霉素和异烟肼）联合使用，持续3个月。计划继续使用每周两次的利福平1，200 mg加异烟肼900 mg，持续15个月，但副作用的高发生率导致只有2名患者完成18个月时停止间歇方案，尽管每日治疗没有严重问题，但11名患者（22%）无法继续使用间歇方案的利福平。8例（16%）发生发热综合征。其中一名患者还出现了暂时性肾衰竭，另一名患者的血小板减少症导致鼻出血和舌唇出血。另外两名患者出现无症状的血小板减少症，总共有3例（6%）血小板减少症，49名患者中有16例（33%）血液中检测到利福平抗体。其中9例（56%）发生了副作用，包括3例发生血小板减少症，但33例患者中仅2例（6%）未检测到抗体。毒性反应与抗体的相关性非常显著（P<0.001）。
Daily rifampicin in a single dose of 600 mg, combined with other drugs, usually streptomycin and isoniazid, was given to 49 patients for three months. It was planned to continue for another 15 months with twice-weekly rifampicin 1,200 mg plus isoniazid 900 mg, but the high incidence of side effects led to cessation of the intermittent regimen when only two patients had completed 18 months.Though there was no serious problem with daily treatment 11 patients (22%) were unable to continue rifampicin on the intermittent regimen. In 8 (16%) a pyrexial syndrome occurred. In one of these patients there was also temporary renal failure, and in another precipitous thrombocytopenia led to epistaxis and bleeding into the tongue and lips. Symptomless thrombocytopenia developed in two other patients, making three cases (6%) of thrombocytopenia in all.In 16 (33%) of the 49 patients antibodies to rifampicin were detected in the blood. Side effects occurred in 9 (56%) of these, including the three developing thrombocytopenia, but in only 2 (6%) of the 33 patients with no antibodies detected. This association of toxic reactions with antibodies is highly significant (P<0·001).