Treatment planning for heavy-ion radiotherapy:: physical beam model and dose optimization
Treatment planning for heavy-ion radiotherapy:: physical beam model and dose optimization
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DOI：
10.1088/0031-9155/45/11/313
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发表时间：
2000-11-01
影响因子：
3.5
通讯作者：
Weber, U
中科院分区：
文献类型：
--
作者：
Krämer, M;Jäkel, O;Weber, U
我们描述了一种新型的编码系统——TRiP，它专门用于高能离子（特别是碳 - 12）放射治疗的规划。该软件旨在与三维主动剂量塑形设备（如GSI光栅扫描系统）协同工作。这种独特的束流传输系统使我们能够从253种单独的束流能量、7种不同的束斑尺寸和15种强度水平的列表中选择任意组合。该软件包含一个适用于碳离子并经过验证的束流模型。为了从临床输入数据（即CT图像和患者轮廓）获得均匀的靶区剂量分布，实施了逆向规划技术。这意味着自动生成多达40000个光栅点的重离子调强场，其中每个点对应一个特定的束流位置、能量和粒子注量。这组数据直接传递给束流传输和控制系统。自1997年12月GSI试点项目启动以来，该治疗规划编码已在临床中使用。已有48名患者得到了成功的规划和治疗。
We describe a novel code system, TRiP, dedicated to the planning of radiotherapy with energetic ions, in particular C-12. The software is designed to cooperate with three-dimensional active dose shaping devices like the GSI raster scan system. This unique beam delivery system allows us to select any combination from a list of 253 individual beam energies, 7 different beam spot sizes and 15 intensity levels. The software includes a beam model adapted to and verified for carbon ions. Inverse planning techniques are implemented in order to obtain a uniform target dose distribution from clinical input data, i.e. CT images and patient contours. This implies the automatic generation of intensity modulated fields of heavy ions with as many as 40 000 raster points, where each point corresponds to a specific beam position, energy and particle fluence. This set of data is directly passed to the beam delivery and control system. The treatment planning code has been in clinical use since the start of the GSI pilot project in December 1997. Forty-eight patients have been successfully planned and treated.