Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET
Lateralization of the serotonin-1A receptor distribution in language areas revealed by PET
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DOI：
10.1016/j.neuroimage.2008.11.033
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发表时间：
2009-04-01
期刊：
影响因子：
5.7
通讯作者：
Lanzenberger, Rupert
中科院分区：
文献类型：
--
作者：
Fink, Martin;Wadsak, Wolfgang;Lanzenberger, Rupert
偏侧化是人类大脑的一个很好的描述。大量的形态、细胞学和功能研究描述了听觉和语言区域的半球不对称。然而，到目前为止，还没有关于活体健康人脑皮质在神经递质受体水平和与功能组织有关的研究报道。在这项研究中，我们评估了主要的抑制性5-羟色胺能受体(5-HT1a受体)的分布，并分析了其与大脑半球、性别和血浆性类固醇激素(睾酮、雌二醇、孕酮)水平的区域结合。我们用高选择性和特异性的放射配基[羰基-C-11]Way-100635用正电子发射断层扫描定量了5-HT1a受体的结合潜力，并测量了34名(女性16名，男性18名)健康右利手受试者的激素水平。获得的数据在基于感兴趣区(ROI)的自动化方法中被分析，该方法调查了14个听觉、语言和边缘区域。5-HT1a受体结合率在右半球额上回、额中回、额下回的三角部和眼眶部、缘上回、颞极上回和颞中回均有显著升高。左侧初级和次级听觉皮质(赫氏回和颞上回)以及罗兰迪氏盖的受体结合量明显较高。5-HT1a受体结合率右侧额区高1.8~2.9%，左侧初级和次级听区高2~3.6%。大脑半球的5-HT1a受体在海马区、杏仁核和脑岛的结合量没有差异。HOC后测试表明，额叶下回三角区5-HT1a受体结合的偏侧化程度在性别间存在差异。这项PET研究首次显示，在活体健康人脑中，5-羟色胺能系统的主要抑制性受体在功能不对称的有组织区域中的偏侧化。(C)2008年，爱思唯尔公司出版。
Lateralization is a well described aspect of the human brain. A plethora of morphological, cytological and functional studies describes hemispheric asymmetry in auditory and language areas. However, no study has reported cortical lateralization in the healthy human brain in vivo on the level of neurotransmitter receptors and in relation to functional organization so far. In this study, we assessed the distribution of the main inhibitory serotonergic receptor (the 5-HT1A receptor) and analyzed its regional binding with regard to hemisphere, sex and plasma levels of sex steroid hormones (testosterone, estradiol, progesterone). We quantified the 5-HT1A receptor binding potential by positron emission tomography (PET) using the highly selective and specific radioligand [carbonyl-C-11] WAY-100635 and measured hormone levels in thirty-four (16 females, 18 males) healthy right- handed subjects. The obtained data were analyzed in an automated region of interest (ROI) based approach investigating 14 auditory, language and limbic areas. We found significantly higher 5-HT1A receptor binding in the superior and middle frontal gyri of the right hemisphere, the triangular and orbital parts of the inferior frontal gyrus, the supramarginal gyrus, the superior gyrus of the temporal pole and the middle temporal gyrus. Regions of the primary and secondary auditory cortex (Heschl's gyrus and superior temporal gyrus) and the Rolandic operculum displayed significantly higher receptor binding in the left hemisphere. 5-HT1A receptor binding was 1.8-2.9% higher in right frontal ROIs and 2-3.6% higher in left primary and secondary auditory regions. There was no hemispheric difference in 5-HT1A receptor binding in the hippocampus, amygdala, and insula. Post-hoc testing suggested that lateralization of 5-HT1A receptor binding differed between the sexes in the triangular part of the inferior frontal gyrus. For the first time, this PET study shows lateralization of the main inhibitory receptor of the serotonergic system in functionally asymmetric organized regions of the healthy human brain in vivo. (C) 2008 Published by Elsevier Inc.