Carbonylation of functionalized diamine diols to cyclic ureas: application to derivatives of DMP 450
Carbonylation of functionalized diamine diols to cyclic ureas: application to derivatives of DMP 450
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DOI：
10.1016/j.tet.2011.04.015
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发表时间：
2011-06-03
期刊：
影响因子：
2.1
通讯作者：
McElwee-White, Lisa
中科院分区：
文献类型：
--
作者：
Darko, Ampofo K.;Curran, F. Chris;McElwee-White, Lisa
通过W（CO）（6）/I-2催化的二胺中间体羰基化反应合成了HIV蛋白酶抑制剂P450的环脲核心结构。相关的官能化的二胺的羰基化的衍生物的EST 450核心结构也进行了检查。选择的二胺二醇底物可以通过催化羰基化转化为环脲核心结构，而不需要保护二醇官能团。(C)2011爱思唯尔有限公司保留所有权利。
Synthesis of the cyclic urea core structure of the HIV protease inhibitor DMP 450 has been achieved via W(CO)(6)/I-2-catalyzed carbonylation of diamine intermediates. Carbonylations of related functionalized diamines to derivatives of the DMP 450 core structure were also examined. Selected diamine diol substrates could be converted to the cyclic urea core structure by catalytic carbonylation without protection of the diol functionality. (C) 2011 Elsevier Ltd. All rights reserved.