Laminar dynamics of beta bursts in human motor cortex
Laminar dynamics of beta bursts in human motor cortex
复制标题
人类运动皮层β爆发的层流动力学
DOI：
10.1101/2021.02.16.431412
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Bonaiuto J
中科院分区：
文献类型：
--
作者：
Bonaiuto J
运动皮层在β频率范围内的活动是最强烈和研究最多的运动相关神经信号之一。在单次试验水平上，β带活动通常以瞬态、高振幅、爆发事件而不是缓慢调制振荡为特征。这些爆发事件的时间与行为密切相关，这表明β活动的功能比之前认为的更动态。然而，感觉运动回路中β爆发的神经机制尚不清楚。为了解决这个问题，我们在这里利用并扩展了高精度脑磁图的最新发展，用于暂时解决的脉冲活动层流分析，并结合了模拟驱动β脉冲电流的生物物理发生器的新皮层电路模型。这种方法精确地指出，人类运动皮层中β爆发的产生是由于皮层深层和表层不同的兴奋性突触输入，它们驱动电流向相反的方向流动。这些运动皮层β爆发的层流动力学与先前在体感觉皮层内的侵入性动物记录一致，并表明了体感觉和运动皮层β爆发的保守机制。更一般地说，我们展示了揭示人类非侵入性记录中事件相关神经信号的层流动力学的能力。这为关于突发活动在健康和疾病运动控制中的功能作用的理论提供了重要的限制，以及在人类测量的宏观现象和从动物模型中记录的微电路活动之间的关键联系。
Motor cortical activity in the beta frequency range is one of the strongest and most studied movement-related neural signals. At the single trial level, beta band activity is often characterized by transient, high amplitude, bursting events rather than slowly modulating oscillations. The timing of these bursting events is tightly linked to behavior, suggesting a more dynamic functional role for beta activity than previously believed. However, the neural mechanisms underlying beta bursts in sensorimotor circuits are poorly understood. To address this, we here leverage and extend recent developments in high precision MEG for temporally resolved laminar analysis of burst activity, combined with a neocortical circuit model that simulates the biophysical generators of the electrical currents which drive beta bursts. This approach pinpoints the generation of beta bursts in human motor cortex to distinct excitatory synaptic inputs to deep and superficial cortical layers, which drive current flow in opposite directions. These laminar dynamics of beta bursts in motor cortex align with prior invasive animal recordings within the somatosensory cortex, and suggest a conserved mechanism for somatosensory and motor cortical beta bursts. More generally, we demonstrate the ability for uncovering the laminar dynamics of event-related neural signals in human non-invasive recordings. This provides important constraints to theories about the functional role of burst activity for movement control in health and disease, and crucial links between macro-scale phenomena measured in humans and micro-circuit activity recorded from animal models.
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影响因子：
3.7
作者：
Felleman, Daniel J.;Van Essen, David C.
通讯作者：
Van Essen, David C.
影响因子：
5.7
作者：
Jurkiewicz, Michael T.;Gaetz, William C.;Cheyne, Douglas
通讯作者：
Cheyne, Douglas
影响因子：
2.5
作者：
H. Tokuno;J. Tanji
通讯作者：
H. Tokuno;J. Tanji
MEG 非侵入式层流推理：方法和源反演算法的比较
DOI：
10.1101/147215
发表时间：
2017
期刊：
--
影响因子：
--
作者：
Bonaiuto J
通讯作者：
Bonaiuto J
DOI：
10.1101/644682
发表时间：
2019-05
期刊：
The Journal of Neuroscience
影响因子：
--
作者：
J. Wessel
通讯作者：
J. Wessel