Use of resting-state fMRI in planning epilepsy surgery.
Use of resting-state fMRI in planning epilepsy surgery.
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DOI：
10.4103/neuroindia.ni_823_16
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发表时间：
2017-01-01
期刊：
影响因子：
2.7
通讯作者：
Engel, Jerome
中科院分区：
文献类型：
--
作者：
Chiang, Sharon;Haneef, Zulfi;Engel, Jerome
癫痫发作是由异常的神经元兴奋性和同步引起的，影响全世界0.5-1%的人口。虽然抗癫痫药物通常是有效的，但相当数量的癫痫患者仍然经历难治性癫痫发作，因此需要手术切除。虽然标准的术前评估依赖于颅内脑电图（icEEG）和直接皮层刺激来识别切除会产生临床缺陷的致痫组织和皮层区域，但icEEG的侵入性和有限的空间范围导致了对微创成像方式作为术前检查辅助工具的研究。在过去的几十年里，功能连接MRI已经成为一种很有前途的手术前定位方法，导致用于识别癫痫组织的方法和生物标志物数量激增。本文综述了功能连接MRI在术前规划中的应用进展，包括癫痫定位和脑皮层成像。
Epileptic seizures result from abnormal neuronal excitability and synchronization, affecting 0.5-1% of the population worldwide. Although anti-seizure drugs are often effective, a significant number of patients with epilepsy continue to experience refractory seizures and are candidates for surgical resection. Whereas standard presurgical evaluation has relied on intracranial electroencephalography (icEEG) and direct cortical stimulation to identify epileptogenic tissue and areas of cortex for which resection would produce clinical deficits, the invasive nature and limited spatial extent of icEEG has led to the investigation of less invasive imaging modalities as adjunctive tools in the presurgical workup. In the past few decades, functional connectivity MRI has emerged as a promising approach for presurgical mapping, leading to a surge in the number of proposed methods and biomarkers for identifying epileptogenic tissue. This review focuses on recent advances in the use of functional connectivity MRI toward its application for presurgical planning, including epilepsy localization and eloquent cortex mapping.