SYNAPTIC ACTIVATION OF VOLTAGE-GATED CHANNELS IN THE DENDRITES OF HIPPOCAMPAL PYRAMIDAL NEURONS
SYNAPTIC ACTIVATION OF VOLTAGE-GATED CHANNELS IN THE DENDRITES OF HIPPOCAMPAL PYRAMIDAL NEURONS
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DOI：
10.1126/science.7716525
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发表时间：
1995-04-14
期刊：
影响因子：
56.9
通讯作者：
JOHNSTON, D
中科院分区：
文献类型：
--
作者：
MAGEE, JC;JOHNSTON, D
通过同时树突附着的膜片钳记录和海马切片 CA1 锥体神经元的全细胞体细胞电压记录，测试了局部突触输入对树突电压门控离子通道的激活。谢弗侧支刺激引发阈下兴奋性突触后电位（EPSP），打开顶端树突中的电压门控钠通道和钙通道。 EPSP 激活的钠通道在 EPSP 峰值附近打开，而低电压激活的钙通道在 EPSP 峰值附近和衰减阶段打开。树突高压激活通道需要体细胞动作电位产生或阈上突触序列来激活。因此，树突电压门控通道可能参与突触事件的树突整合。
Activation of dendritic voltage-gated ion channels by local synaptic input was tested by simultaneous dendrite-attached patch-clamp recordings and whole-cell somatic voltage recordings made from CA1 pyramidal neurons in hippocampal slices. Schaffer collateral stimulation elicited subthreshold excitatory postsynaptic potentials (EPSPs) that opened voltage-gated sodium and calcium channels in the apical dendrites. The EPSP-activated sodium channels opened near the peak of the EPSP, whereas low voltage-activated calcium channels opened near the EPSP peak and during the decay phase. Dendritic high voltage-activated channels required somatic action potential generation or suprathreshold synaptic trains for activation. Dendritic voltage-gated channels are, therefore, likely to participate in dendritic integration of synaptic events.