Intrauterine growth restriction - impact on cardiovascular diseases later in life.
Intrauterine growth restriction - impact on cardiovascular diseases later in life.
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DOI：
10.1186/s40348-018-0082-5
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发表时间：
2018-03-20
期刊：
影响因子：
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通讯作者：
Hartner A
中科院分区：
文献类型：
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作者：
Menendez-Castro C;Rascher W;Hartner A
宫内生长受限（IUGR）是一种胎儿病理，导致某些新生儿并发症的风险增加。此外，临床和实验研究表明，IUGR与生命后期代谢、肾脏和心血管疾病（CVD）的发生率显著升高有关。关于IUGR后CVD风险增加的一个假设是，IUGR诱导代谢改变，从而导致CVD。这篇综述主要关注最近的研究，这些研究表明IUGR之后是早期原发性心血管改变，这些改变可能在以后的生活中直接发展为CVD。
Intrauterine growth restriction (IUGR) is a fetal pathology which leads to increased risk for certain neonatal complications. Furthermore, clinical and experimental studies revealed that IUGR is associated with a significantly higher incidence of metabolic, renal and cardiovascular diseases (CVD) later in life. One hypothesis for the higher risk of CVD after IUGR postulates that IUGR induces metabolic alterations that then lead to CVD. This minireview focuses on recent studies which demonstrate that IUGR is followed by early primary cardiovascular alterations which may directly progress to CVD later in life.