Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium (Hormoscilla sp., Oscillatoriales)
Isolation and Characterization of Anaephenes A-C, Alkylphenols from a Filamentous Cyanobacterium (Hormoscilla sp., Oscillatoriales)
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DOI：
10.1021/acs.jnatprod.8b00650
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发表时间：
2018-12-01
影响因子：
5.1
通讯作者：
Luesch, Hendrik
中科院分区：
文献类型：
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作者：
Brumley, David;Spencer, Kara A.;Luesch, Hendrik
从关岛采集的一种未描述的丝状蓝细菌（VPG 16-59）中分离出三种相关的新烷基酚，称为anaephenes A-C（1-3），含有不同的侧链。16 S rDNA序列分析结果表明，VPG 16-59属于海洋颤藻目（Oscillatoriales）藻属Hormoscilla。通过光谱方法鉴定了Anaephenes A-C（1-3）的结构，并测定了化合物对原核和真核细胞系的生长抑制活性。Anaephene B（2）具有末端炔，对蜡状芽孢杆菌和金黄色葡萄球菌显示中等活性，MIC值为6.1 μ g/mL。虽然1和3在这些测定中没有显示出明显的活性，但它们的结构特征突出了这种蓝藻的不寻常的生物合成能力，并值得进一步研究。
Three related new alkylphenols, termed anaephenes A-C (1-3), containing different side chains, were isolated from an undescribed filamentous cyanobacterium (VPG 16-59) collected in Guam. Our 16S rDNA sequencing efforts indicated that VPG 16-59 is a member of the marine genus Hormoscilla (Oscillatoriales). The structures of anaephenes A-C (1-3) were elucidated by spectroscopic methods, and compounds assayed for growth inhibitory activity against prokaryotic and eukaryotic cell lines. Anaephene B (2), possessing a terminal alkyne, displayed moderate activity against Bacillus cereus and Staphylococcus aureus with MIC values of 6.1 mu g/mL. While 1 and 3 showed no pronounced activity in these assays, their structural features highlight the unusual biosynthetic capacity of this cyanobacterium and warrant further study.