p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.
p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells.
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DOI：
10.3109/07357900903286941
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发表时间：
2010-07
影响因子：
2.4
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Zhang J;Lu A;Li L;Yue J;Lu Y
The degree of tumor progression (such as growth, angiogenesis, and metastasis) directly correlates with the expression of vascular endothelial growth factor (VEGF), but inversely correlates with the expression of tumor-suppressor gene p16, therefore we examined whether the restoration of p16 in breast cancer cells would modulate VEGF expression. Adenoviral-mediated p16 expression downregulated VEGF gene expression in breast cancer cells, and inhibited breast cancer cell-induced angiogenesis by a dorsal air sac model in mice. Moreover, p16 appears to form a complex with HIF-1α, the transcription factor for the VEGF gene promoter. Taken together, the binding between p16 and HIF-1α protein may alter HIF-1α’s ability to transactivate VEGF expression.
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影响因子：
11.2
作者：
Liao, Debbie;Corle, Courtney;Johnson, Randall S.
通讯作者：
Johnson, Randall S.
影响因子：
6.4
作者：
Lu, Y;Carraher, J;Steiner, MS
通讯作者：
Steiner, MS
影响因子：
50.3
作者：
Mabjeesh, NJ;Escuin, D;Giannakakou, P
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Giannakakou, P
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作者：
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Szalay, AA
DOI：
10.1093/jnci/89.2.139
发表时间：
1997-01-15
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Gasparini, G;Toi, M;Tominaga, T
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Tominaga, T