Cognitive Lifestyle and Long-Term Risk of Dementia and Survival After Diagnosis in a Multicenter Population-based Cohort
Cognitive Lifestyle and Long-Term Risk of Dementia and Survival After Diagnosis in a Multicenter Population-based Cohort
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DOI：
10.1093/aje/kwq476
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发表时间：
2011-05-01
影响因子：
5
通讯作者：
Matthews, Fiona
中科院分区：
文献类型：
--
作者：
Valenzuela, Michael;Brayne, Carol;Matthews, Fiona
积极的认知生活方式与痴呆症的发病率和生存率有关，但其子成分的单独和综合影响尚不清楚。数据来源于医学研究理事会认知功能和老龄化研究，这是一项以人口为基础的研究，在1991-1992年首次采访了英格兰和威尔士的13，004人，并随访了10年的痴呆症发病率和12年的死亡率。认知生活方式评分（CLS），定义为认知活动的复合，包括教育，职业复杂性和社会参与，可用于12，600人的3个生命阶段。较高的CLS对痴呆症有保护作用（比值比= 0.6，95%置信区间：0.4，0.9）。敏感性分析发现，即使只考虑分数的两个组成部分，即教育和职业或教育和晚年社会参与，这种主效应也是可靠和可复制的。没有单一的CLS因素与痴呆症的发病率有关。生存差异未达到统计学显著性。我们的数据表明，更多年的教育，以及在中年或晚年的进一步刺激经验。是痴呆症发病率的保护性联系所必需的。几乎没有证据表明认知生活方式对痴呆症诊断后的生存率有影响。
An active cognitive lifestyle has been linked to dementia incidence and survival, but the separate and combined effects of its subcomponents are not clear. Data were derived from the Medical Research Council Cognitive Function and Ageing Study, a population-based study of 13,004 individuals in England and Wales first interviewed in 1991-1992 and followed over a 10-year period for dementia incidence and 12 years for mortality. A Cognitive Lifestyle Score (CLS), defined as a composite of cognitive activity including education, occupational complexity, and social engagement, was available for 12,600 individuals in 3 stages of life. A higher CLS was protective of dementia (odds ratio = 0.6, 95% confidence interval: 0.4, 0.9). Sensitivity analyses found this main effect to be reliable and replicable even when considering just 2 components of the score, either education and occupation or education and late-life social engagement. No single CLS factor was associated with dementia incidence on its own. Survival differences did not reach statistical significance. Our data suggest that more years of education, as well as further stimulatory experiences in either midlife or late life. are necessary for a protective link with dementia incidence. There was little evidence of an effect of cognitive lifestyle on survival after dementia diagnosis.