Synthesis of an amphiphilic tetraantennary mannosyl conjugate and incorporation into liposome carriers
Synthesis of an amphiphilic tetraantennary mannosyl conjugate and incorporation into liposome carriers
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DOI：
10.1016/s0960-894x(03)00472-4
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发表时间：
2003-08-04
影响因子：
2.7
通讯作者：
Frisch, B
中科院分区：
文献类型：
--
作者：
Espuelas, S;Haller, P;Frisch, B
We have synthesized a novel conjugate (Man(4)K(3)DOG) composed of a tetramannosyl head group connected, via a polyethylene glycol spacer, to a lipid moiety. This amphiphilic molecule was easily incorporated into the bilayers of liposomes. As expected from the clustering effect, such multivalent mannose residues when exposed on the surface of the vesicles showed much higher binding affinity for Concanavalin A than their monomannosyl analogue. Mannosylated liposomes prepared with the tetravalent antenna could be promising carriers for e.g., loading dendritic cells with antigens for vaccination purposes. (C) 2003 Elsevier Ltd. All rights reserved.
