Multicomponent reactions: advanced tools for sustainable organic synthesis
Multicomponent reactions: advanced tools for sustainable organic synthesis
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DOI：
10.1039/c4gc00013g
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发表时间：
2014-01-01
期刊：
影响因子：
9.8
通讯作者：
Orru, Romano V. A.
中科院分区：
文献类型：
--
作者：
Cioc, Razvan C.;Ruijter, Eelco;Orru, Romano V. A.
可持续或绿色化学已经建立了坚实的基础，为复杂的高附加值分子的有效化学合成的发展提供了基本的设计标准。另一方面，多组分反应直到最近才被认为是合成化学家工具箱的主要扩展。然而，人们仍然很少认识到这些类型的反应的实用价值，以满足绿色化学哲学所设定的许多标准，以指导有机化学家和工艺化学家设计，合成和进一步开发真正可持续的药物，食品添加剂，催化剂或先进材料的制造工艺。在这个角度来看，我们强调多组分反应的效用作为绿色合成的方法。
Sustainable or green chemistry has established firm ground providing essential design criteria for the development of efficient chemical syntheses of complex, high added value molecules. On the other hand, multicomponent reactions have only recently been recognized as major expansion of the synthetic chemist's toolbox. There is still little awareness, however, of the practical value of these type of reactions for meeting many of the criteria set by the green chemistry philosophy to guide organic chemists and process chemists in the design, synthesis and further development of truly sustainable manufacturing processes of medicines, food additives, catalysts or advanced materials. In this perspective we highlight the utility of multicomponent reactions as methods for green synthesis.