Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.
Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI.
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DOI：
10.1002/jor.21125
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发表时间：
2010-09
影响因子：
2.8
通讯作者：
Nunley, James A.
中科院分区：
文献类型：
--
作者：
Chuckpaiwong, Bavornrit;Charles, Hal Cecil;Kraus, Virginia B.;Guilak, Farshid;Nunley, James A.
肥胖作为骨关节炎的主要危险因素，已被证明可以改变关节负荷，但也可能导致代谢变化，其特征是由于脂肪衍生细胞因子或“脂肪因子”循环水平的增加而出现慢性、低水平的炎症。膝盖骨下脂肪垫的存在表明局部脂肪因子浓度的变化可能会影响膝骨性关节炎。这项研究检验了这样的假设，即膝下脂肪垫的体积与骨关节炎患者的身体质量指数(BMI)相关，以及骨关节炎患者的脂肪垫体积更大。在15名对照组和15名膝骨性关节炎受试者的队列中，脂肪垫体积被测量在一年多的序列磁共振图像中。在基线、3个月、6个月或12个月时，两组之间的脂肪垫体积没有差异。在对照组中，任何参数(年龄、BMI、体重、任何时间点的脂肪垫体积)之间都没有显著的相关性。然而，在骨关节炎组中，脂肪垫体积在每个时间点都与年龄相关。一种可能的解释是，与膝骨性关节炎有关的局部因素也可能导致脂肪垫随着年龄的增长而增大。或者，容易出现脂肪垫生长或增大的受试者也可能更容易出现症状性骨关节炎。这些发现为膝下脂肪垫在骨关节炎中的潜在作用提供了有趣的初步数据，尽管还需要更多的研究来更好地了解这种关系的机制。
Obesity, as a primary risk factor for osteoarthritis, has been shown to alter joint loading, but may also result in metabolic changes characterized by chronic, low-level inflammation due to increased circulating levels of adipose-derived cytokines, or “adipokines”. The presence of the infrapatellar fat pad in the knee suggests that local changes in adipokine concentrations may influence knee osteoarthritis. This study examined the hypotheses that the volume of the infrapatellar fat pad is correlated to the body mass index (BMI) of osteoarthritis patients, and that fat pad volume is greater in subjects with osteoarthritis. Fat pad volume was measured in sequential magnetic resonance images taken over one year in a cohort of 15 control and 15 knee osteoarthritis subjects. No differences were observed in the fat pad volume between the two groups at baseline, 3, 6, or 12 months. In control subjects, no significant correlations were present between any parameters (age, BMI, weight, volume of fat pad at any time point). However, in the osteoarthritic group, fat pad volume was correlated with age at every time point. One possible explanation is that local factors related to knee osteoarthritis may also induce enlargement of the fat pad with age. Alternatively, subjects who are prone to growth or enlargement of the fat pad may also be more prone to symptomatic osteoarthritis. These findings provide intriguing preliminary data on the potential role of the infrapatellar fat pad in osteoarthritis, although additional study is required to better understand the mechanisms of this relationship.
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影响因子：
--
作者：
Griffin, Timothy M.;Huebner, Janet L.;Kraus, Virginia B.;Guilak, Farshid
通讯作者：
Guilak, Farshid
影响因子：
2.8
作者：
Ghazzawi, Ahmad;Theobald, Peter;Nokes, Len
通讯作者：
Nokes, Len
影响因子：
2.3
作者：
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通讯作者：
Rühmann, O
影响因子：
5.8
作者：
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通讯作者：
Maerz, Winfried
影响因子：
1.4
作者：
Özkur, A;Adaletli, I;Bayram, M
通讯作者：
Bayram, M