Mitochondrial dynamism and heart disease: changing shape and shaping change.
Mitochondrial dynamism and heart disease: changing shape and shaping change.
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DOI：
10.15252/emmm.201404575
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发表时间：
2015-07
影响因子：
11.1
通讯作者：
Dorn GW 2nd
中科院分区：
文献类型：
--
作者：
Dorn GW 2nd
成体心肌细胞的线粒体表现为低动力，缺乏相互连接的网状网络和在许多其他细胞类型中观察到的持续分裂和融合。然而，线粒体网络重构所必需的蛋白质在成人心脏中是丰富的。最近心脏特异性消融线粒体分裂和融合蛋白基因的研究结果揭示了线粒体动力学因素在线粒体自噬线粒体质量控制中的意想不到的作用。本文综述了支持和反对线粒体动力学-质量控制相互作用组在正常和患病心脏中的有意义作用的临床和实验证据。新发现的线粒体动力学因子在维持最佳心脏线粒体健康方面的功能表明，对临床心肌病的深入研究可能会揭示通过影响线粒体裂变、融合和线粒体自噬导致或改变心脏病的遗传变异。
Mitochondria of adult cardiomyocytes appear hypo-dynamic, lacking interconnected reticular networks and the continual fission and fusion observed in many other cell types. Nevertheless, proteins essential to mitochondrial network remodeling are abundant in adult hearts. Recent findings from cardiac-specific ablation of mitochondrial fission and fusion protein genes have revealed unexpected roles for mitochondrial dynamics factors in mitophagic mitochondrial quality control. This overview examines the clinical and experimental evidence for and against a meaningful role for the mitochondrial dynamism–quality control interactome in normal and diseased hearts. Newly discovered functions of mitochondrial dynamics factors in maintaining optimal cardiac mitochondrial fitness suggest that deep interrogation of clinical cardiomyopathy is likely to reveal genetic variants that cause or modify cardiac disease through their effects on mitochondrial fission, fusion, and mitophagy.