EXPERIMENTAL STRESS-FRACTURES OF THE TIBIA - BIOLOGICAL AND MECHANICAL ETIOLOGY IN RABBITS
EXPERIMENTAL STRESS-FRACTURES OF THE TIBIA - BIOLOGICAL AND MECHANICAL ETIOLOGY IN RABBITS
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DOI：
10.1302/0301-620x.72b3.2341429
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发表时间：
1990-05-01
影响因子：
--
通讯作者：
RADIN, EL
中科院分区：
文献类型：
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作者：
BURR, DB;MILGROM, C;RADIN, EL
我们已经证明，应力性骨折可以诱导在胫骨骨干的动物模型的反复应用的非创伤性冲击负荷。31只家兔右后肢负重3 ~ 9周，用X线片和骨密度计监测骨的变化。在某些病例中，组织学证实存在应力性骨折。大多数动物在6周内发生应力性骨折，骨密度变化与放射学证据之间存在正对应关系。在骨扫描阳性部位，显微镜下可见明显损伤。该动物模型中应力性骨折的进展、位置和发作时间与临床报告中的相似，使该模型成为研究应力性骨折病因学的有用模型。
We have shown that stress fractures can be induced in the tibial diaphysis of an animal model by the repeated application of non-traumatic impulsive loads. The right hind limbs of 31 rabbits were loaded for three to nine weeks and changes in the bone were monitored by radiography and bone scintigraphy. The presence of stress fractures was confirmed histologically in some cases. Most animals sustained a stress fracture within six weeks and there was a positive correspondence between scintigraphic change and radiological evidence. Microscopic damage was evident at the sites of positive bone scans. The progression, location, and time of onset of stress fractures in this animal model were similar to those in clinical reports, making the model a useful one for the study of the aetiology of stress fractures.