Genomic polymorphic profiles in an Irish population with meningococcaemia: is it possible to predict severity and outcome of disease?
Genomic polymorphic profiles in an Irish population with meningococcaemia: is it possible to predict severity and outcome of disease?
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DOI：
10.1038/sj.gene.6364020
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发表时间：
2003-12-01
影响因子：
5
通讯作者：
Smith, OP
中科院分区：
文献类型：
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作者：
Balding, J;Healy, CM;Smith, OP
脑膜炎球菌病患者血浆中促炎细胞因子IL-6、il -1 β和tnf - α水平升高，且水平升高与死亡结局相关。本研究调查了编码这些细胞因子的基因多态性，以及编码抗炎IL-10和IL-1Ra的基因多态性是否与脑膜炎球菌病患者的预后相关。对183例脑膜炎球菌病患者和389例对照组进行了7种多态性基因分型。IL-6 - 174 G/G和IL-10 - 1082 A/A基因型在非幸存者中比在幸存者中更常见（P = 0.023 IL-6, 0.25 IL-10），在重症患者中比轻症患者更常见（P = 0.037 IL-6, 0.0078 IL-10）。还发现脑膜炎球菌病与IL-1RN VNTR多态性之间存在关联，但未观察到与LTA + 252、TNF - 308、IL-10 - 592或IL-1B + 3953多态性相关。我们得出结论，IL-6、IL-10和IL-1RN基因的遗传变异与脑膜炎球菌病的不良预后有关。
Patients with meningococcal disease have increased plasma levels of proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha, with higher levels associated with fatal outcome. This study investigated whether polymorphisms in genes encoding these cytokines, and in those encoding anti-inflammatory IL-10 and IL-1Ra, are associated with the outcome in patients with meningococcal disease. Seven polymorphisms were genotyped in 183 meningococcal disease patients and 389 controls. The IL-6 - 174 G/G and IL-10 - 1082 A/A genotypes were more frequent in nonsurvivors compared with survivors (P = 0.023 IL-6, 0.25 IL-10), and in patients with severe disease compared to those with mild disease (P = 0.037 IL-6, 0.0078 IL-10). An association was also found between meningococcal disease and the IL-1RN VNTR polymorphism, but no association was observed with the LTA + 252, TNF - 308, IL-10 - 592, or IL-1B + 3953 polymorphisms. We conclude that genetic variability in the IL-6, IL-10, and IL-1RN genes is associated with a poor outcome in meningococcal disease.