Beyond Range: Innovating Fluorescence Microscopy
Beyond Range: Innovating Fluorescence Microscopy
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DOI：
10.3390/rs4010111
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发表时间：
2012-01-01
期刊：
影响因子：
5
通讯作者：
Esposito, Alessandro
中科院分区：
文献类型：
--
作者：
Esposito, Alessandro
飞行时间（ToF）技术主要用于工业应用或消费产品中的距离估计。最近，人们意识到ToF传感器也可以用于检测荧光和荧光分子的纳秒电子态的微小变化。这种能力可以用来报告生物体内发生的生化过程。因此，ToF技术为分子和细胞生物学、诊断学和药物发现提供了新的机会。在这篇简短的通讯中，讨论了工程和生物医学界对ToF技术的融合及其对基础科学、应用科学和转化科学的潜在影响。
Time-of-Flight (ToF) technologies are developed mainly for range estimations in industrial applications or consumer products. Recently, it was realized that ToF sensors could also be used for the detection of fluorescence and of the minute changes in the nanosecond-lived electronic states of fluorescent molecules. This capability can be exploited to report on the biochemical processes occurring within living organisms. ToF technologies, therefore, provide new opportunities in molecular and cell biology, diagnostics, and drug discovery. In this short communication, the convergence of the engineering and biomedical communities onto ToF technologies and its potential impact on basic, applied and translational sciences are discussed.