Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease.
Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease.
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DOI：
10.1172/jci24930
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发表时间：
2005-05
期刊：
影响因子：
--
通讯作者：
S. Tamura;I. Shimomura
中科院分区：
文献类型：
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作者：
S. Tamura;I. Shimomura
非酒精性脂肪性肝病（NAFLD）是代谢综合征的一个组成部分，临床范围从单纯性脂肪肝到脂肪性肝炎、肝硬化和肝细胞癌。NAFLD的主要事件是肝细胞中甘油三酯（tag）的积累。在本期的JCI中，Donnelly等人报道了他们使用稳定同位素方法表明，储存在脂肪组织中的脂肪酸和肝脏内通过新生脂肪生成新生成的脂肪酸是肝脏中tag的主要来源，并在NAFLD中以脂蛋白的形式分泌。
Nonalcoholic fatty liver disease (NAFLD) is a component of the metabolic syndrome, with a clinical spectrum ranging from simple fatty liver to steatohepatitis, cirrhosis, and hepatocellular carcinoma. The primary event of NAFLD is the accumulation of triacylglycerols (TAGs) in hepatocytes. In this issue of the JCI, Donnelly et al. report on their use of stable isotope methodology to show that fatty acids stored in adipose tissue and fatty acids newly made within the liver through de novo lipogenesis are the major sources of TAGs in the liver and are secreted as lipoproteins in NAFLD.