EVALUATION OF SHORT-TERM OUTCOMES OF INTRAVITREAL AFLIBERCEPT INJECTIONS FOR AGE-RELATED MACULAR DEGENERATION USING FOCAL MACULAR ELECTRORETINOGRAPHY.
EVALUATION OF SHORT-TERM OUTCOMES OF INTRAVITREAL AFLIBERCEPT INJECTIONS FOR AGE-RELATED MACULAR DEGENERATION USING FOCAL MACULAR ELECTRORETINOGRAPHY.
复制标题
使用局灶黄斑视网膜电图评估玻璃体内注射 AFLIBERCEPT 治疗年龄相关性黄斑变性的短期结果。
DOI：
10.1097/iae.0000000000001225
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
Terasaki H.
中科院分区：
文献类型：
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作者：
Takayama K;Kaneko H;Ueno S;Maruko R;Piao CH;Yasuda S;Kawano K;Ito Y;Terasaki H.
目的：评估湿性老年性黄斑变性患者玻璃体内注射阿柏西普（IVA）后，黄斑部视网膜电图的形态学改变与功能改善之间的关系。方法：回顾性分析42例42只眼连续接受3个月IVA治疗的单纯湿性老年性黄斑变性患者的临床记录。比较两组最佳矫正视力、中心凹厚度、外视网膜厚度、内视网膜厚度及黄斑部视网膜电图的变化（P= 0.0091）。中心凹厚度和外视网膜厚度在每次IVA后均明显减小（P< 0.001）。视网膜内层厚度在第二次IVA后（P= 0.002）、第三次IVA后（P= 0.001）降低。在焦点黄斑视网膜电图上，第三次IVA后a和b波振幅显示增加（分别为P= 0.0028，P= 0.0012）。最佳矫正视力与中央凹厚度、a波振幅与外视网膜厚度、b波振幅与内视网膜厚度的变化在第三次IVA后均呈显著相关性。结论：所有参数在三个月IVA后均显著恢复，功能改善与形态学变化相关。
Purpose:To evaluate the relationship between morphological changes and functional improvements assessed using focal macular electroretinograms after intravitreal aflibercept (IVA) injections in eyes with wet age-related macular degeneration.Methods:The clinical records of 42 eyes of 42 consecutive patients with naive, wet age-related macular degeneration received 3 monthly IVA were reviewed. The best-corrected visual acuity, central foveal thickness, outer retinal thickness, inner retinal thickness at baseline and 1 month after each IVA, and focal macular electroretinograms at baseline and 1 month after the first and third IVA were compared.Results:Best-corrected visual acuity was improved after the third IVA (P= 0.0091). Central foveal thickness and outer retinal thickness showed decreases after every IVA (P< 0.001, respectively). Inner retinal thickness showed a decrease after the second IVA (P= 0.002), after and third IVA (P= 0.001). On focal macular electroretinograms, a-and b-wave amplitudes showed increases after the third IVA (P= 0.0028, P= 0.0012, respectively). Significant correlations were observed between best-corrected visual acuity and central foveal thickness, a-wave amplitude and outer retinal thickness, and b-wave amplitude and inner retinal thickness changes after the third IVA.Conclusion:All parameters significantly recovered after three monthly IVA, with a correlation between functional improvements and morphological changes.