Symptoms of depression and anxiety in anorexia nervosa: Links with plasma tryptophan and serotonin metabolism.
Symptoms of depression and anxiety in anorexia nervosa: Links with plasma tryptophan and serotonin metabolism.
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DOI：
10.1016/j.psyneuen.2013.09.009
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发表时间：
2014-01-01
影响因子：
3.7
通讯作者：
Godart, Nathalie
中科院分区：
文献类型：
--
作者：
Gauthier, Claire;Hassler, Christine;Godart, Nathalie
抑郁、焦虑和强迫症状经常与神经性厌食症（AN）同时发生。这些临床表现与饥饿引起的生物学变化之间的关系尚不清楚。据推测，色氨酸（TRP）的可用性降低可能会降低血清素活性，从而引发这些共病症状。本研究的目的是，在AN患者的再喂养期间，分析营养状况、抑郁和焦虑症状以及外周血清素标记物的测量之间的协变。对42名AN参与者在入院治疗时和再次治疗后的血浆TRP以及TRP与大分子中性氨基酸的比值进行了评估。喂食生物措施进行了比较，在42个非进食障碍的主题。对于那些与AN，心理，营养和生物参数在住院期间显着改善。在入院和出院时，AN组的血清素标志物水平显著低于对照组。TRP/LNAA比值的增加与抑郁症状的减少相关。此外，出院时血清素水平与焦虑和抑郁症状呈正相关。我们推测，增强TRP的可用性在重新喂养，由于TRP/LNAA比例的增加，可以恢复5-羟色胺神经传递，并导致抑郁症状的减少。血清素与焦虑和抑郁症状之间的关联与大量观察结果一致，这些观察结果表明AN患者的胆碱能系统功能异常。(C)2013爱思唯尔有限公司版权所有。
Depressive, anxiety and obsessive symptoms frequently co-occur with anorexia nervosa (AN). The relationship between these clinical manifestations and the biological changes caused by starvation is not well understood. It has been hypothesised that reduced availability of tryptophan (TRP) could reduce serotonin activity and thus trigger these comorbid symptoms. The aim of this study, during re-feeding in individuals with AN, was to analyse covariations across measures of nutritional status, depressive and anxiety symptoms, and peripheral serotonin markers.Depressive and anxiety symptoms, nutritional status and serotonin markers -whole blood serotonin content, plasma TRP and the ratio between TRP and large neutral amino acids - were assessed for 42 AN participants at admission to inpatient treatment and after re-feeding. Biological measures were compared to those obtained in 42 non-eating disordered subjects. For those with AN, psychological, nutritional and biological parameters improved significantly during hospitalisation. Levels of serotonin markers were significantly lower in the AN group compared to the control group, at admission and at discharge. Increase in the TRP/LNAA ratio was correlated with a decrease in depressive symptoms. In addition, there was a positive correlation between serotonin levels and symptoms of both anxiety and depression at discharge. We speculate that enhanced TRP availability during re-feeding, as a result of the increase in the TRP/LNAA ratio, could restore serotonin neurotransmission and lead to a decrease in depressive symptoms. The association between serotonin and anxiety and depressive symptoms would be consistent with numerous observations indicating abnormal functioning of the serotoninergic system in AN. (C) 2013 Elsevier Ltd. All rights reserved.