Diabetes and retinal vascular dysfunction.
Diabetes and retinal vascular dysfunction.
复制标题
DOI：
10.4103/2008-322x.143378
复制
发表时间：
2014-07
影响因子：
2
通讯作者：
Sheibani N
中科院分区：
文献类型：
--
作者：
Shin ES;Sorenson CM;Sheibani N
糖尿病主要影响视网膜的微血管循环，导致该组织特有的一系列结构变化。这些变化最终导致渗透性改变、内皮细胞过度增殖和水肿，以及视网膜的异常血管化，从而导致视力丧失。炎症介质和氧化应激的产生增加是糖尿病视网膜病变（DR）发病机制的主要损伤。我们已经确定了高血糖症影响的视网膜血管细胞的身份，并描绘了高葡萄糖对这些细胞功能的细胞自主影响。我们讨论了一些高葡萄糖视网膜血管细胞的具体变化和他们的视网膜血管功能障碍的贡献。这些知识为糖尿病视网膜病变的发展和进展提供了分子和细胞缺陷的新见解，并将有助于开发用于预防和治疗DR的创新和靶向特异性治疗方法。
Diabetes predominantly affects the microvascular circulation of the retina resulting in a range of structural changes unique to this tissue. These changes ultimately lead to altered permeability, hyperproliferation of endothelial cells and edema, and abnormal vascularization of the retina with resulting loss of vision. Enhanced production of inflammatory mediators and oxidative stress are primary insults with significant contribution to the pathogenesis of diabetic retinopathy (DR). We have determined the identity of the retinal vascular cells affected by hyperglycemia, and have delineated the cell autonomous impact of high glucose on function of these cells. We discuss some of the high glucose specific changes in retinal vascular cells and their contribution to retinal vascular dysfunction. This knowledge provides novel insight into the molecular and cellular defects contributing to the development and progression of diabetic retinopathy, and will aid in the development of innovative, as well as target specific therapeutic approaches for prevention and treatment of DR.