QUANTITATIVE STUDIES OF ADOPTIVE IMMUNOLOGICAL MEMORY IN MICE .2. LINEAR TRANSMISSION OF CELLULAR MEMORY
QUANTITATIVE STUDIES OF ADOPTIVE IMMUNOLOGICAL MEMORY IN MICE .2. LINEAR TRANSMISSION OF CELLULAR MEMORY
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DOI：
10.1084/jem.125.2.199
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发表时间：
1967-01-01
影响因子：
15.3
通讯作者：
CELADA, F
中科院分区：
文献类型：
--
作者：
CELADA, F
A calibrated cell transfer system allows detection of the anamnestic response to albumin without interference from the host''s immune machinery; it was used to study the immunological memory of mouse spleen cell populations. The secondary antibody-forming capacity of the transferred cells was measured by challenging them at periods up to 6 months after transfer. The peak levels attained show a declining pattern in 2 phases: during the 1st month with a half-life of 15 days; thereafter, with a half-life of 100 days. The corresponding half-lives of the cellular memory are 26 and 190 days. In the light of these and of radioinactivation data, immunological memory is defined as the persistence of a specifically determined stem cell line, along which the information necessary to give rise to an antibody-forming cell population is transmitted from mother to daughter cells.
