Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer
Expression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancer
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DOI：
10.1093/annonc/mdg002
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发表时间：
2003-01-01
影响因子：
50.5
通讯作者：
Aglianò, AM
中科院分区：
文献类型：
--
作者：
Gazzaniga, P;Gradilone, A;Aglianò, AM
背景资料：已经表明，浅表性膀胱癌的进展可能在分子水平上通过参与细胞凋亡的基因的典型表达模式来调节。LIVIN属于凋亡抑制因子（inhibitors of apoptosis，IAP）家族，近年来发现其在大多数实体瘤中表达，其表达被认为具有预后意义。没有数据是关于LIVIN在膀胱tumors.Patients和方法的进展的意义：在本文中，我们使用RT-PCR研究LIVIN亚型α和β，SURVIVIN，BCL-X和BCL-2/BAX的表达比在正常和肿瘤膀胱组织的表达，并与他们的表达出现的早期复发的后续4年。结果：30例膀胱癌中7例（23%）表达LIVIN，9例（30%）表达SURVIVIN，16例（53%）表达BCL-2/BAX，BCL-2/BAX比值>1。
Background: It has been suggested that progression of superficial bladder cancer may be regulated at the molecular level by a typical pattern of expression of genes involved in apoptosis. Recently LIVIN, belonging to the inhibitors of apoptosis (IAP) family, has been found to be expressed in most solid tumors, where its expression is suggested to have prognostic significance. No data are available concerning the significance of LIVIN in the progression of bladder tumors.Patients and methods: In the present paper we used RT-PCR to investigate the expression of LIVIN isoforms alpha and beta, SURVIVIN, BCL-X and BCL-2/BAX expression ratio both in normal and tumoral bladder tissues, and correlated their expression with the emergence of early relapses in a follow-up of 4 years. This study shows that only the alpha isoform of LIVIN, which is not expressed in normal bladder tissue, is expressed in a proportion of tumors with a high risk of relapse.Results: LIVIN was found in 7/30 patients (23%), SURVIVIN in 9/30 (30%), BCL-2/BAX ratio >1 in 16/30 (53%), BCL-2/BAX expression ratio