The positive and negative consequences of stressors during early life.
The positive and negative consequences of stressors during early life.
复制标题
DOI：
10.1016/j.earlhumdev.2015.08.008
复制
发表时间：
2015-11
影响因子：
2.5
通讯作者：
Haussmann MF
中科院分区：
文献类型：
--
作者：
Monaghan P;Haussmann MF
我们讨论了在出生前和出生后早期暴露于压力的长期影响。我们提出了一个进化框架，在此框架内可以审视这些影响，并描述了结果如何因物种的生活史而异。我们聚焦于那些会导致糖皮质激素增加的压力源，并讨论了一种实验方法的优势。我们描述了一些研究，这些研究表明在生命早期接触这些激素如何影响应激反应，并对成年后的寿命产生重大的长期负面后果。我们还描述了在生命早期接触轻度压力源如何对后期生活中的抗压能力产生有益影响，并讨论了成本和收益的平衡如何可能取决于成年环境的性质。
We discuss the long-term effects of stress exposure in pre- and early postnal life. We present an evolutionary framework within which such effects can be viewed, and describe how the outcomes might vary with species life histories. We focus on stressors that induce increases in glucocorticoid hormones and discuss the advantages of an experimental approach. We describe a number of studies demonstrating how exposure to these hormones in early life can influence stress responsiveness and have substantial long-term, negative consequences for adult longevity. We also describe how early life exposure to mild levels of stressors can have beneficial effects on resilience to stress in later life, and discuss how the balance of costs and benefits is likely dependent on the nature of the adult environment.