Altered catecholamine contents in vascular and nonvascular tissues in genetically hypertensive rats.
Altered catecholamine contents in vascular and nonvascular tissues in genetically hypertensive rats.
复制标题
遗传性高血压大鼠血管和非血管组织中儿茶酚胺含量的改变。
DOI：
10.1159/000158601
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Stitzel,RE
中科院分区：
文献类型：
--
作者：
Head,RJ;Cassis,LA;Robinson,RL;Westfall,DP;Stitzel,RE
本文测定了遗传性高血压大鼠（SHR）和正常血压京都-Wistar大鼠（WKY）心脏、肠系膜血管、腹主动脉、下腔静脉、输精管和唾液腺中的儿茶酚胺（CA）含量。我们注意到SHR和WKY大鼠个体组织中去甲肾上腺素（NE）含量之间的差异，并使用了两种不同的分析方法来测量NE以确认这些差异。SHR和WKY大鼠组织中NE含量的比较表明，SHR的心脏、肠系膜动脉、腹主动脉、下腔静脉和输精管中NE含量较高。在SHR大鼠的肾上腺中观察到NE适度升高[但未观察到肾上腺素（E）]。SHR和WKY大鼠唾液腺NE含量无明显差异。结果提示，SHR大鼠外周血管中NE含量可能普遍增高。此外，这种增加也存在于输精管中，而不是唾液腺。结果引起注意的NE在血管和选定的非血管组织中的SHR的浓度改变。
We have measured the catecholamine (CA) contents in hearts, mesenteric vasculature, abdominal aorta, inferior vena cava, vasa deferentia and salivary glands from genetically hypertensive rats (SHR) and normotensive Kyoto-Wistar rats (WKY). We noted differences between the norepinephrine (NE) contents of individual tissues from SHR and WKY rats and have used two different analytical procedures for the measurement of NE to confirm these differences. Comparisons between tissue contents of NE in SHR and WKY rats indicated a greater content of NE in the following tissues from the SHR: heart, mesenteric artery, abdominal aorta, inferior vena cava and vasa deferentia. A modest elevation of NE [but not epinephrine (E)] was observed in adrenal glands from SHR rats. The NE contents of salivary glands from SHR and WKY rats were indistinguishable from each other. The results suggest that there may exist a generalized increase in NE contents in the peripheral vasculature of SHR rats. Furthermore, this increase is also present in the vasa deferentia, but not the salivary gland. The results draw attention to altered concentrations of NE in vascular and selected nonvascular tissues in the SHR.