Pharmacological significance of the species differences in bupropion metabolism.
Pharmacological significance of the species differences in bupropion metabolism.
复制标题
安非他酮代谢物种差异的药理学意义。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
D. H. Schroeder
中科院分区：
文献类型：
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作者：
R. Welch;A. Lai;D. H. Schroeder
Bupropion provided a dose-dependent prevention of tetrabenazine-induced sedation in mice but not rats. Bupropion was extensively metabolized in mice, rats, dogs and man. About 85% of the dose was excreted in urine of rats and man. The predominant metabolites in rat urine were side chain cleavage products of bupropion (m-chlorobenzoic acid) with a minor fraction consisting of basic side chain hydroxylated metabolites. Mice, dogs and man form a major side chain hydroxylated product (BW 306U) which appeared in higher concentration than bupropion in plasma of these species but not rats. The relatively high plasma levels of BW 306U in mice but not rats may account for the species difference in pharmacological response observed with bupropion.
