Evolutional and developmental anatomical architecture of the left inferior frontal gyrus
Evolutional and developmental anatomical architecture of the left inferior frontal gyrus
复制标题
左额下回的进化和发育解剖结构
DOI：
10.1016/j.neuroimage.2020.117268
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发表时间：
2020-11-15
期刊：
影响因子：
5.7
通讯作者：
Tan, Li-Hai
中科院分区：
文献类型：
--
作者：
Wang, Jiaojian;Yang, Yang;Tan, Li-Hai
包括Broca区域在内的左下额回（IFG）参与了许多语言子域的处理，因此，对左IFG的进化和人类发展特征的研究将阐明语言的出现和成熟。在这项研究中，我们使用扩散磁共振成像（DMRI）和静止状态功能性MRI（fMRI）来研究人类左IFG的进化和发育模式（6-8岁，年龄在11-13岁，年龄11-13岁，年龄16-18岁）和猕猴。基于拖拉机的拟层用于定义左IFG的子组件，并始终识别人类和猕猴的四个子区域。每个子区域的特定共激活模式和功能表征支持了人类左IFG的这种分析方案。在进化和发展过程中，我们发现功能平衡增加，低频波动的幅度，功能整合和功能耦合。我们还观察到较高的分数各向异性值，即在进化和发育过程中更好地骨髓和腹侧白质语言途径。我们假设静止状态功能连接性和与任务相关的共激活映射与分层语言处理相关联。我们的发现表明，左IFG的进化和人类发展模式将有助于理解人类语言的发展以及非典型语言发展障碍的发生。
The left inferior frontal gyrus (IFG) including Broca's area is involved in the processing of many language subdomains, and thus, research on the evolutional and human developmental characteristics of the left IFG will shed light on how language emerges and maturates. In this study, we used diffusion magnetic resonance imaging (dMRI) and resting-state functional MRI (fMRI) to investigate the evolutional and developmental patterns of the left IFG in humans (age 6-8, age 11-13, and age 16-18 years) and macaques. Tractography-based parcellation was used to define the subcomponents of left IFG and consistently identified four subregions in both humans and macaques. This parcellation scheme for left IFG in human was supported by specific coactivation patterns and functional characterization for each subregion. During evolution and development, we found increased functional balance, amplitude of low frequency fluctuations, functional integration, and functional couplings. We also observed higher fractional anisotropy values, i.e. better myelination of dorsal and ventral white matter language pathways during evolution and development. We assume that the resting-state functional connectivity and task-related coactivation mapping are associated with hierarchical language processing. Our findings have shown the evolutional and human developmental patterns of left IFG, and will contribute to the understanding of how the human language evolves and how atypical language developmental disorders may occur.