Functional lateralization of the sensorimotor cortex in patients with schizophrenia: Effects of treatment with olanzapine
Functional lateralization of the sensorimotor cortex in patients with schizophrenia: Effects of treatment with olanzapine
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DOI：
10.1016/j.biopsych.2004.04.009
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发表时间：
2004-08-01
影响因子：
10.6
通讯作者：
Nardini, M
中科院分区：
文献类型：
--
作者：
Bertolino, A;Blasi, G;Nardini, M
背景资料：早期的横断面研究与功能性磁共振成像（fMRI）在治疗的精神分裂症患者的报告异常的皮质运动处理，包括减少偏侧的初级感觉运动皮层。本纵向研究的目的是评估此类皮质异常是否代表该疾病的状态或特征现象。方法：在奥氮平治疗4周和8周后对17名患有急性疾病、先前未经治疗的患者进行了研究。17名匹配的健康受试者作为对照受试者。所有受试者进行两次功能磁共振成像扫描4周间隔在视觉起搏的运动任务，使用一个简单的周期性块设计。在统计参数映射（SPM 99）中分析功能磁共振成像数据。感兴趣区域分析用于确定偏侧商数结果：功能磁共振成像数据表明，患者在4周时初级感觉运动皮层的激活减少，但在8周时没有减少;然而，在两个时间点，患者初级感觉运动皮层的偏侧商数减少。这些结果表明，在运动处理过程中的一些皮质异常代表状态现象，而减少初级感觉运动复合体的功能偏侧化提出了精神分裂症的一个持久的特点。
Background: Earlier cross-sectional studies with functional magnetic resonance imaging (fMRI) in treated patients with schizophrenia have reported abnormalities of cortical motor processing, including reduced lateralization of primary sensory motor cortex. The objective of the present longitudinal study was to evaluate whether such cortical abnormalities represent state or trait phenomena of the disorder.Methods: Seventeen acutely ill, previously untreated patients were studied after 4 weeks and after 8 weeks of olanzapine therapy. Seventeen matched healthy subjects served as control subjects. All subjects underwent two fMRI scans 4 weeks apart during a visually paced motor task using a simple periodic block design. Functional magnetic resonance imaging data were analyzed in Statistical Parametric Mapping (SPM99). Region of interest analyses were used to determine a laterality quotient (an index of lateralization) of motor cortical regions.Results: The fMRI data indicated that patients bad reduced activation of the primary sensory motor cortex at 4 weeks but not at 8 weeks; however, the laterality quotient in the primary sensory motor cortex was reduced in patients at both time points.Conclusions: These results suggest that some cortical abnormalities during motor processing represent state phenomena, whereas reduced functional lateralization of the primary sensory motor complex presents an enduring trait of schizophrenia.