Alzheimer's deterioration in intellectual and neurobiological staging supports the retrogenesis model: a double dissociation between verbal/non-verbal judgments and the left/right parieto-temporal glucose metabolism. A retrospective data analysis from the
Alzheimer's deterioration in intellectual and neurobiological staging supports the retrogenesis model: a double dissociation between verbal/non-verbal judgments and the left/right parieto-temporal glucose metabolism. A retrospective data analysis from the
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阿尔茨海默病智力和神经生物学分期的恶化支持了逆生模型：言语/非言语判断与左/右顶颞叶葡萄糖代谢之间的双重分离。
DOI：
10.1111/psyg.12478
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Tashiro M.
中科院分区：
文献类型：
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作者：
Meguro M;Meguro K;Takahashi K;Yamaguchi S;Tashiro M.
背景阿尔茨海默病(AD)患者表现出与儿童相似的各种临床特征(逆生型)。比奈测试可以用来评估智力的发展和恶化。然而，神经影像的相关性仍有待澄清。尽管AD患者也表现出社会判断障碍，但与如此多的记忆测试相反，认知测试很少。在数据库中，我们注意到比奈测验包括使用不合逻辑的句子和图片的社会判断的分量表。本研究的目的是为了阐明比奈测验的神经影像相关性，特别是对于不合逻辑的问题。采用田中-比奈测验评定心理年龄和基础年龄。后者是患者在较低的年龄水平上可以完全完成所有问题的年龄水平，用于计算心理年龄。使用不合逻辑的句子/图片的分测验评估逻辑判断能力。使用磁共振成像，我们对皮质萎缩进行了四级视觉评估。采用18F-脱氧葡萄糖-正电子发射断层扫描(FDG-PET)放射自显影方法测定脑葡萄糖代谢率(CMRglc)。额叶、颞叶和海马区萎缩程度与基础年龄相关。整个灰质、额叶和颞叶CMRglc与基础年龄相关。不合逻辑句得分与双侧颞叶、海马区和左侧顶颞区CMRglc相关，而不合逻辑图片得分与右侧顶颞区CMRglc相关。结论额叶和颞叶萎缩及代谢低下与基础年龄有关。关于不合逻辑的判断，目前的正电子发射计算机断层扫描数据分析显示，言语/非言语判断和左/右顶叶-颞区之间可能存在双重分离。
BackgroundAlzheimer disease (AD) patients demonstrate various clinical features reminiscent of children (the retrogenesis model). The Binet test is available for assessing mental development and deterioration. However, neuroimaging correlations remain to be clarified. Although AD patients also manifest social judgment disability, there are few cognitive tests, contrary to so many memory tests. Among the database, we noticed that the Binet test includes the subscale of social judgement using illogical sentences and pictures. The aim of this study is to clarify the neuroimaging correlations for the Binet test, especially for the illogical questions.MethodsForty participants were selected from the database of the Tajiri Project. The Tanaka‐Binet test was used to evaluate the mental age and the basic age. The latter is the age level at which the patient can completely accomplish all questions at the immediately lower age level and is used for calculating the mental age. Using the subtests of illogical sentences/pictures, logical judgment abilities were assessed. Using magnetic resonance imaging, we performed four‐grade visual evaluation for cortical atrophy. The cerebral metabolic rate for glucose (CMRglc) was measured using an autoradiographic method of18F‐fluoreodeoxyglucose – positron emission tomography (FDG‐PET).ResultsThere was a significant Spearman's correlation between the clinical stage and the basic age. Degree of frontal, temporal and hippocampal atrophy were correlated with the basic age. The entire grey matter and frontal and temporal CMRglc were associated with the basic age. The illogical sentences scores were correlated with the bilateral temporal, hippocampal and the left parieto‐temporal CMRglc, whereas the illogical picture scores were correlated with the right parieto‐temporal CMRglc.ConclusionsWe found that frontal and temporal atrophy as well as hypometabolism were associated with the basic age. Regarding the illogical judgment, the current PET data analysis disclosed that there may be a double dissociation between verbal/non‐verbal judgments and the left/right parieto‐temporal areas.