Enigmatic variations: the many facets of CFTR function in the heart.
Enigmatic variations: the many facets of CFTR function in the heart.
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DOI：
10.1111/apha.13525
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发表时间：
2020-06
影响因子：
6.3
通讯作者：
A. James
中科院分区：
文献类型：
--
作者：
A. James
人们早就知道心肌细胞释放ATP，并且ATP的释放在缺氧和缺血的反应中增加。然而，这种释放及其调控的机制尚不清楚。在这一期的《生理学报》上，Wang和来自Ballard实验室的同事们提出了有趣的新证据，证明囊性纤维化跨膜传导调节剂（CFTR）在模拟缺血反应中从心肌细胞释放ATP的作用。
It has long been known that cardiac myocytes release ATP, and that the release of ATP is increased in response to hypoxia and ischaemia. The mechanisms underlying that release and its regulation, however, remain unclear. In this issue of Acta Physiologica, Wang and colleagues from the Ballard lab present intriguing new evidence of a role for the cystic fibrosis transmembrane conductance regulator (CFTR) in the release of ATP from cardiac myocytes in response to simulated ischaemia.