Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder
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DOI：
10.1111/j.1399-5618.2007.00467.x
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发表时间：
2007-08-01
影响因子：
5.4
通讯作者：
Post, Robert M.
中科院分区：
文献类型：
--
作者：
Kupka, Ralph W.;Altshuler, Lori L.;Post, Robert M.
目的：在纵向研究的大型双相受试者队列中，评估躁狂、抑郁和心境的时间比例，并调查双相I型与双相II型患者的抑郁/躁狂比例。方法：对自然治疗的双相情感障碍I型（n = 405）或双相情感障碍II型（n = 102）门诊患者进行为期一年的临床调整的情绪自我评定。分析了平均平静、抑郁、躁狂、轻躁和循环的时间，并比较了两组患者患病时间的百分比。结果：双相情感障碍I型和II型患者患病时间百分比分别为：精神状态为47.7%和50.2%；抑郁症36.0% vs 37.0%；轻躁狂11.5% vs 9.8%；狂躁1.0%对0.2%；骑车率为3.7%对2.8%。双相情感障碍I亚组抑郁/躁狂比率为2.9，双相情感障碍II亚组为3.8。结论：抑郁症是门诊双相I型和II型患者的主要异常情绪状态。与其他研究相反，我们发现抑郁/躁狂的比例是相似的，这表明在两个亚组中情绪不稳定的趋势是相同的。
Objectives: To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder.Methods: Clinician-adjusted self-ratings of mood were completed daily for one year for naturalistically treated outpatients with bipolar I (n = 405) or bipolar II (n = 102) disorder. Ratings were analyzed for mean time spent euthymic, depressed, manic, hypomanic, and cycling, and the percentages of time spent ill were compared between the two groups.Results: Percentages of time spent ill for bipolar I versus II patients were: euthymia 47.7% versus 50.2%; depression 36.0% versus 37.0%; hypomania 11.5% versus 9.8%; mania 1.0% versus 0.2%; and cycling 3.7% versus 2.8%. The depression/mania ratio was 2.9 in the bipolar I and 3.8 in bipolar II sub-groups.Conclusions: Depression represents the predominant abnormal mood state for treated outpatients with bipolar I and II disorder. In contrast to other studies, we found that depression/mania ratios were of a similar magnitude, suggesting the same tendency towards mood instability in both sub-groups.