Sex-specific, rapid neuroestrogen fluctuations and neurophysiological actions in the songbird auditory forebrain
Sex-specific, rapid neuroestrogen fluctuations and neurophysiological actions in the songbird auditory forebrain
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DOI：
10.1152/jn.00749.2011
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发表时间：
2012-03-01
影响因子：
2.5
通讯作者：
Schlinger, B. A.
中科院分区：
文献类型：
--
作者：
Remage-Healey, L.;Dong, S. M.;Schlinger, B. A.
Remage-Healey L，Dong SM，Chao A，Schlinger BA.鸣禽听觉前脑的性别特异性、快速神经雌激素波动和神经生理作用。J Neurophysiol 107：1621-1631，2012.首次发表于2011年12月21日; doi：10.1152/jn.00749.2011.-最近的证据表明，脑源性类固醇，如雌激素（“神经雌激素”）的控制方式非常类似于传统的神经递质。在鸣禽类固醇体内微透析的出现提供了新的信息的空间和时间动态的神经雌激素的变化在听觉皮层的区域，尾内侧巢皮质（NCM）。在这里，使用体内微透析的实验表明，神经雌二醇（E-2）波动发生在听觉NCM在呈现自然的听觉和视觉刺激的男性，但只有在女性的听觉刺激的介绍。这些变化是急性的（30分钟内），似乎是特定的NCM，因为类似的治疗引起附近的系膜区域或循环血浆中的E-2没有变化。进一步的实验耦合在体内类固醇微透析与细胞外记录在NCM显示，神经雌激素迅速提高听觉反应的歌曲刺激的女性，类似于最近的观察男性。我们还发现，雌二醇对听觉反应的快速作用完全模仿细胞膜不可渗透的雌激素生物素，与急性雌激素作用在神经元膜一致。因此，我们的结论是，局部和急性E-2流量调节的收敛多模态的感觉输入，这种调节似乎是性别特异性的。第二，在NCM的本地E-2水平的快速变化的调制的听觉处理的女性和男性的后果。最后，神经雌激素对NCM听觉处理的快速作用似乎是由非经典的膜结合雌激素受体介导的。
Remage-Healey L, Dong SM, Chao A, Schlinger BA. Sex-specific, rapid neuroestrogen fluctuations and neurophysiological actions in the songbird auditory forebrain. J Neurophysiol 107: 1621-1631, 2012. First published December 21, 2011; doi:10.1152/jn.00749.2011.-Recent evidence shows that brain-derived steroids such as estrogens ("neuroestrogens") are controlled in a manner very similar to traditional neurotransmitters. The advent of in vivo microdialysis for steroids in songbirds has provided new information about the spatial and temporal dynamics of neuroestrogen changes in a region of the auditory cortex, the caudomedial nidopallium (NCM). Here, experiments using in vivo microdialysis demonstrate that neuroestradiol (E-2) fluctuations occur within the auditory NCM during presentation of naturalistic auditory and visual stimuli in males but only to the presentation of auditory stimuli in females. These changes are acute (within 30 min) and appear to be specific to the NCM, because similar treatments elicit no changes in E-2 in a nearby mesopallial region or in circulating plasma. Further experiments coupling in vivo steroid microdialysis with extracellular recordings in NCM show that neuroestrogens rapidly boost auditory responses to song stimuli in females, similar to recent observations in males. We also find that the rapid actions of estradiol on auditory responses are fully mimicked by the cell membrane-impermeable estrogen biotinylestradiol, consistent with acute estrogen actions at the neuronal membrane. Thus we conclude that local and acute E-2 flux is regulated by convergent multimodal sensory input, and that this regulation appears to be sex-specific. Second, rapid changes in local E-2 levels in NCM have consequences for the modulation of auditory processing in females and males. Finally, the rapid actions of neuroestrogens on NCM auditory processing appear to be mediated by a nonclassical, membrane-bound estrogen receptor.