The spindle checkpoint
The spindle checkpoint
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DOI：
10.1016/s0959-437x(99)80010-0
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发表时间：
1999-02-01
影响因子：
4
通讯作者：
Amon, A
中科院分区：
文献类型：
--
作者：
Amon, A
在姐妹染色单体分离之前，纺锤体检查点抑制细胞周期进程，以响应有丝分裂纺锤体损伤或未附着于微管的染色体产生的信号。最近的工作表明，纺锤体检查点通过直接将纺锤体检查点途径的组件与负责触发姐妹染色单体分离的特殊泛素结合系统的组件结合来抑制细胞周期进展。
Prior to sister-chromatid separation, the spindle checkpoint inhibits cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules. Recent work has shown that the spindle checkpoint inhibits cell-cycle progression by direct binding of components of the spindle checkpoint pathway to components of a specialized ubiquitin-conjugating system that is responsible for triggering sister-chromatid separation.