Characterizing the relationship between HIV-1 genotype and phenotype: Prediction-based classification
Characterizing the relationship between HIV-1 genotype and phenotype: Prediction-based classification
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DOI：
10.1111/j.0006-341x.2002.00145.x
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发表时间：
2002-03-01
期刊：
影响因子：
1.9
通讯作者：
De Gruttola, V
中科院分区：
文献类型：
--
作者：
Foulkes, AS;De Gruttola, V
This paper establishes a framework for understanding the complex relationships between HIV-1 genotypic markers of resistance to antiretroviral drugs and clinical measures of disease progression. A new classification scheme based on the probabilities of how new patients will respond to antiretroviral therapy given the available data is proposed as a method for distinguishing among groups of viral sequences. This approach draws from existing cluster analysis, discriminant analysis, and recursive partitioning techniques and requires a model relating genotypic characteristics to phenotypic response. A data set of 2746 sequences and the corresponding Indinavir 50% inhibitory concentrations are described and used for illustrative purposes.
