Outdoor Air Pollution and Term Low Birth Weight in Japan
Outdoor Air Pollution and Term Low Birth Weight in Japan
复制标题
日本的室外空气污染与足月低出生体重
DOI：
10.1016/j.envint.2014.09.003
复制
发表时间：
2015
影响因子：
11.8
通讯作者：
Hiroyuki Doi
中科院分区：
文献类型：
--
作者：
Takashi Yorifuji;Saori Kashima;Hiroyuki Doi
前言环境空气污染与不良生育结局之间的关系已经积累了大量的证据。然而，以前的大多数研究都是在地理位置不同的地区进行的，缺乏重要的潜在协变量。我们利用2001年开始的日本全国人口纵向调查的数据，检验了环境空气污染对足月低出生体重(LBW)的影响。方法我们限制参与者只能有足月单胎(n=44,109)。出生前9个月的空气污染浓度是在市政府一级获得的，并分配给在相应市政府出生的参与者。结果发现孕期空气污染暴露与足月低体重儿的风险呈正相关。在完全调整的模型中，每种污染物在一个四分位数范围内增加后的优势比分别为：悬浮颗粒物(SPM)1.09(95%可信区间：1.00，1.19)，二氧化氮(NO2)1.11(0.99，1.26)，二氧化硫(SO2)1.71(1.18，2.46)。具体地说，在怀孕前三个月，对SPM和NO2暴露的影响估计高于其他三个月，而SO2在所有三个月都与风险相关。不吸烟的母亲比吸烟的母亲更容易接触SPM和NO2。结论在日本具有全国代表性的样本中，环境空气污染增加了LBW的风险。
IntroductionEvidence has accumulated on the association between ambient air pollution and adverse birth outcomes. However, most of the previous studies were conducted in geographically distinct areas and suffer from lack of important potential covariates. We examined the effect of ambient air pollution on term low birth weight (LBW) using data from a nationwide population-based longitudinal survey in Japan that began in 2001.MethodsWe restricted participants to term singletons (n = 44,109). Air pollution concentrations during the 9 months before birth were obtained at the municipality level and were assigned to the participants who were born in the corresponding municipality. We conducted multilevel logistic regression analyses adjusting for individual and municipality-level variables.ResultsWe found that air pollution exposure during pregnancy was positively associated with the risk of term LBW. In the fully adjusted models, odds ratios following one interquartile range increase in each pollutant were 1.09 (95% confidence interval: 1.00, 1.19) for suspended particulate matter (SPM), 1.11 (0.99, 1.26) for nitrogen dioxide (NO2), and 1.71 (1.18, 2.46) for sulfur dioxide (SO2). Specifically, effect estimates for SPM and NO2exposure at the first trimester were higher than those at other trimesters, while SO2was associated with the risk at all trimesters. Nonsmoking mothers were more susceptible to SPM and NO2exposure compared with smoking mothers.ConclusionsAmbient air pollution increases the risk of term LBW in a nationally representative sample in Japan.