Dental infections and atherosclerosis
Dental infections and atherosclerosis
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DOI：
10.1016/s0002-8703(99)70293-0
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发表时间：
1999-11-01
影响因子：
4.8
通讯作者：
Offenbacher, S
中科院分区：
文献类型：
--
作者：
Beck, JD;Pankow, J;Offenbacher, S
在大多数国家，冠心病是发病和死亡的主要原因之一。本报告回顾了目前的证据表明，口腔疾病（特别是牙周炎）可能是动脉粥样硬化及其临床表现的危险因素，并提供了新的初步数据。这篇综述是在研究的背景下进行的，表明炎症在动脉粥样硬化形成中起着核心作用，并且与牙周病相关的全身微生物和炎症负担很大。我们的综述集中在5项纵向研究，这些研究显示口腔疾病与冠心病的发病相关，同时控制了各种既定的冠心病危险因素。除了已发表的证据外，我们的社区牙科动脉粥样硬化风险研究的初步结果也表明，牙周病与颈动脉内膜-中层壁厚度相关，这是亚临床动脉粥样硬化的一种测量方法，调整了已知与这两种情况相关的因素。
In most countries, coronary heart disease is one of the leading causes of morbidity and death. This report reviews the current evidence indicating that oral conditions (specifically periodontitis) may be a risk factor for atherosclerosis and its clinical manifestations and provides new preliminary data. This review is done in the context of the research indicating that inflammation plays a central role in atherogenesis and that there is a substantial systemic microbial and inflammatory burden associated with periodontal disease. Our review concentrates on 5 longitudinal studies that show oral conditions being associated with the onset of coronary heart disease while controlling for a variety of established coronary heart disease risk factors. In addition to published evidence, preliminary Findings from our Dental Atherosclerosis Risk in Communities study also indicate that periodontal disease is associated with carotid intimal-medial wall thickness, a measure of subclinical atherosclerosis, adjusting for factors known to be associated with both conditions.