Mechanisms and inhibition of HIV integration.
Mechanisms and inhibition of HIV integration.
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DOI：
10.1016/j.ddmec.2006.05.004
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发表时间：
2006-07-01
期刊：
影响因子：
--
通讯作者：
Pommier, Yves
中科院分区：
文献类型：
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作者：
Marchand, Christophe;Johnson, Allison A;Pommier, Yves
HIV整合酶是病毒复制所必需的，也是抗逆转录病毒治疗的基本靶点。整合酶抑制剂对当前的治疗方法有潜在的补充作用。本综述着重于艾滋病毒整合的机制。综述了病毒和细胞辅因子在整合前复合物（PIC）形成和整合过程中的作用。整合的生化机制，整合酶的结构和方法来抑制整合。
HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described.