Gene Transfer from Bacteria and Archaea Facilitated Evolution of an Extremophilic Eukaryote
Gene Transfer from Bacteria and Archaea Facilitated Evolution of an Extremophilic Eukaryote
复制标题
DOI：
10.1126/science.1231707
复制
发表时间：
2013-03-08
期刊：
影响因子：
56.9
通讯作者：
Weber, Andreas P. M.
中科院分区：
文献类型：
--
作者：
Schoenknecht, Gerald;Chen, Wei-Hua;Weber, Andreas P. M.
一些微生物真核生物，如极端嗜红菌Galdieria sulphuraria，生活在炎热、有毒、富含金属的酸性环境中。为了阐明适应的潜在分子机制，我们对13.7兆碱基的G.硫磺。这种植物表现出巨大的代谢灵活性，在50多种碳源上以光合自养或异养方式生长。环境适应似乎是由来自各种细菌和古细菌的水平基因转移促进的，通常随后是基因家族的扩张。至少有5%的G.硫磺可能是水平获得的。这些蛋白质参与了从重金属解毒到甘油吸收和代谢的重要生态过程。因此，我们的研究结果表明，泛域基因库促进了这种单细胞真核生物的环境适应。
Some microbial eukaryotes, such as the extremophilic red alga Galdieria sulphuraria, live in hot, toxic metal-rich, acidic environments. To elucidate the underlying molecular mechanisms of adaptation, we sequenced the 13.7-megabase genome of G. sulphuraria. This alga shows an enormous metabolic flexibility, growing either photoautotrophically or heterotrophically on more than 50 carbon sources. Environmental adaptation seems to have been facilitated by horizontal gene transfer from various bacteria and archaea, often followed by gene family expansion. At least 5% of protein-coding genes of G. sulphuraria were probably acquired horizontally. These proteins are involved in ecologically important processes ranging from heavy-metal detoxification to glycerol uptake and metabolism. Thus, our findings show that a pan-domain gene pool has facilitated environmental adaptation in this unicellular eukaryote.