Cloning and expression of canine interleukin-10.

Cloning and expression of canine interleukin-10.
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犬白细胞介素10的克隆和表达。

DOI：
10.1089/jir.1995.15.1103
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发表时间：
1995
期刊：
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
影响因子：
--
通讯作者：
Miller,J
Miller,J
中科院分区：
--
文献类型：
--
作者：
Lu,P;Zucker,K;Fuller,L;Tzakis,A;Esquenazi,V;Miller,J

文献摘要

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相似文献

We describe here the cloning of canine IL-10 cDNA (GenBank accession No. U33843) and the expression of recombinant IL-10 in a dog kidney cell line (DK6247) and Chinese hamster ovary cells (CHO). Canine IL-10 exhibits strong sequence homology to the known sequences of human, mouse, rat, and bovine genes at nucleotide and amino acid levels. The IL-10 gene, when introduced into DK and CHO cell lines, produces recombinant IL--10 that causes an inhibitory effect on allogeneic MHC-driven lymphoproliferative responses.