Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study
Relationship of 3D meniscal morphology and position with knee pain in subjects with knee osteoarthritis: a pilot study
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DOI：
10.1007/s00330-011-2234-z
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发表时间：
2012-01-01
影响因子：
5.9
通讯作者：
Eckstein, Felix
中科院分区：
文献类型：
--
作者：
Wenger, Andrea;Englund, Martin;Eckstein, Felix
为了探索半月板位置和大小的定量、三维测量是否与膝盖疼痛相关，采用人内膝间研究设计。我们研究了来自骨关节炎倡议的 53 名受试者（19 名男性，34 名女性），他们的两个膝盖的放射学 OA 等级相同，但一个膝盖经常疼痛，另一个膝盖没有疼痛。使用冠状重建双回波稳态序列水激励 (DESSwe) MRI 对胫骨平台和半月板进行分析。内侧半月板覆盖胫骨平台的较小部分 (-5%)，并且在疼痛膝关节中比无痛膝关节中表现出更大的身体挤压 (+15%)（配对 t 检验；p < 0.05）。在疼痛的膝盖中，外侧半月板的外部边缘显示出更大的身体挤压（+22%；p = 0.03），但其内部边缘的位置或胫骨覆盖范围没有显着差异。内侧或外侧挤压千分之 3 毫米在疼痛膝关节 (n = 23) 中比在无痛膝关节中 (n = 12；McNemar 检验；p = 0.02) 更常见。未观察到半月板大小与膝关节疼痛之间存在显着关联。这些数据表明，通过定量 MRI 测量，半月板体挤压与膝关节 OA 受试者的膝关节疼痛之间存在相关性。进一步的研究需要证实这些发现及其临床相关性。半月板分割提供了半月板大小/位置的定量测量，在膝盖之间，人内方法可以探索膝盖疼痛的潜在来源半月板挤压可能是膝盖疼痛的潜在来源。
To explore whether quantitative, three-dimensional measurements of meniscal position and size are associated with knee pain using a within-person, between-knee study design.We studied 53 subjects (19 men, 34 women) from the Osteoarthritis Initiative, with identical radiographic OA grades in both knees, but frequent pain in one and no pain in the other knee. The tibial plateau and menisci were analyzed using coronally reconstructed double echo steady-state sequence with water excitation (DESSwe) MRI.The medial meniscus covered a smaller proportion of the tibial plateau (-5%) and displayed greater extrusion of the body (+15%) in painful than in painless knees (paired t-test; p < 0.05). The external margin of the lateral meniscus showed greater extrusion of the body in painful knees (+22%; p = 0.03), but no significant difference in the position of its internal margin or tibial coverage. Medial or lateral extrusion a parts per thousand yen3 mm was more frequent in painful (n = 23) than in painless knees (n = 12; McNemar's test; p = 0.02). No significant association was observed between meniscal size and knee pain.These data suggest a relationship between extrusion of the meniscal body, as measured with quantitative MRI, and knee pain in subjects with knee OA. Further studies need to confirm these findings and their clinical relevance.Meniscal segmentation provides quantitative measures of meniscal size/positionBetween-knee, within-person approaches can explore potential sources of knee painMeniscal extrusion may be a potential source of knee pain.