Mouse models of brain tumors and their applications in preclinical trials
Mouse models of brain tumors and their applications in preclinical trials
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DOI：
10.1158/1078-0432.ccr-06-0438
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发表时间：
2006-09-15
影响因子：
11.5
通讯作者：
Holland, Eric C.
中科院分区：
文献类型：
--
作者：
Fomchenko, Elena I.;Holland, Eric C.
原发性脑肿瘤，包括神经胶质瘤和髓母细胞瘤，通常代表最具破坏性和难以治疗的肿瘤，并且被认为分别来自神经胶质细胞和/或其前体或外部颗粒细胞层。人类脑肿瘤的大多数遗传改变特征被认为发生在编码参与信号转导或细胞周期调节的蛋白质的基因中。使用基因工程小鼠模型准确再现这些遗传改变允许具有相似组织病理学、病因学和生物学的脑肿瘤的体内建模。这些小鼠模型反过来又增加了我们对脑肿瘤起始、形成、进展和转移的理解，为发现新的治疗靶点和测试各种治疗药物提供了实验系统。
Primary brain tumors, including gliomas and medulloblastomas, often represent the most devastating and difficult-to-treat tumors, and are thought to arise from glial cells and/or their precursors or the external granule cell layer, respectively. The majority of genetic alterations characteristic of the human brain tumors are thought to occur in genes encoding proteins involved in signal transduction or cell cycle regulation. Accurate recapitulation of these genetic alterations using genetically engineered mouse models allows for in vivo modeling of brain tumors with similar histopathology, etiology, and biology. These mouse models, in turn, increase our understanding of brain tumor initiation, formation, progression, and metastasis, providing an experimental system to discover novel therapeutic targets and test various therapeutic agents.