Metabolic effects of dietary sucrose and fructose in type II diabetic subjects
Metabolic effects of dietary sucrose and fructose in type II diabetic subjects
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DOI：
10.2337/diacare.19.11.1249
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发表时间：
1996-11-01
期刊：
影响因子：
16.2
通讯作者：
Wajchenberg, BL
中科院分区：
文献类型：
--
作者：
Malerbi, DA;Paiva, ESA;Wajchenberg, BL
目的：研究饮食中果糖和蔗糖对II型糖尿病患者代谢的影响。研究设计与方法：16名控制良好的II型糖尿病患者接受3种等卡路里饮食，每组28天。这三种饮食分别从碳水化合物、蛋白质和脂肪中提供了总能量的50%-55%、15%和30%-35%。在一种饮食中，总卡路里的20%来自果糖；在另一种饮食中，总卡路里的19%来自蔗糖；结果：在血糖控制、血脂水平、胰岛素和C-肽分泌方面，果糖或蔗糖饮食与对照多糖饮食在任何指标上都没有显著差异。结论--我们的数据表明，在中短期内，高果糖和蔗糖饮食不会对控制良好的II型糖尿病患者的血糖、血脂、胰岛素和C-肽分泌产生不利影响。
OBJECTIVE - Tb investigate the metabolic effects of dietary fructose and sucrose in type II diabetic patients.RESEARCH DESIGN AND METHODS - Sixteen well-controlled type II diabetic subjects were fed three isocaloric diets for 28 days each. The three diets provided 50-55, 15, and 30-35% of total energy from carbohydrate, protein, and Fat, respectively. In one diet, 20% of total calories were derived from fructose; in another, 19% of total calories were derived from sucrose; and in the control diet, only 5% of daily calories were derived from sugars, all other carbohydrates being supplied as polysaccharides.RESULTS - No significant differences were observed between either the fructose or the sucrose diet and the control polysaccharide diet in any of the measures of glycemic control, serum lipid levels, or insulin and C-peptide secretion.CONCLUSIONS - Our data suggest that in the short and middle terms, high fructose and sucrose diets do not adversely affect glycemia, lipemia, or insulin and C-peptide secretion in well-controlled type II diabetic subjects.